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Strontium Ranelate information from DrugsUpdate  

See Available Brands of Strontium Ranelate in India

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Strontium ranelate, a strontium(II) salt of ranelic acid, is a medication for osteoporosis marketed as Protelos or Protos by Servier. It is unusual in the sense that it both increases deposition of new bone osteoblasts and reduces the resorption of bone by osteoclasts. It is therefore promoted as a "dual action bone agent" (DABA).

Pharmacodynamics

Pharmacokinetics

Strontium ranelate increases bone formation in bone tissue culture as well as osteoblast precursor replication and collagen synthesis in bone cell culture. It also reduces bone resorption by decreasing osteoclast differentiation and resorbing activity. This results in a rebalance of bone turnover in favour of bone formation.

Absorption
Oral bioavailability: about 25%. May be reduced by calcium or food.

Distribution

Low protein binding.

Metabolism
Not metabolised.

Excretion

Half-life: 60 hours. Excreted via kidneys and GI tract.

Strontium Ranelate Indications / Strontium Ranelate Uses

Information Not Available

Strontium Ranelate Adverse Reactions / Strontium Ranelate Side Effects

Nausea and diarrhoea. Headache, loose stools and eczema. Transient reversible increases in creatine kinase activity.

Precautions

Information Not Available

Special Precautions

Not recommended for use in patients with CrCl <30 ml/minutes. Patients at increased risk of venous thromboembolism.

Other Drug Interactions

Food, milk and derivative products, and medicinal products containing calcium may reduce the bioavailability of strontium ranelate. May reduce the absorption of oral tetracycline and quinolone antibiotics.

Other Interactions

Information Not Available

Dosage

Oral
Postmenopausal osteoporosis
Adult: 2 g daily.
CrCl (ml/min)    Dosage Recommendation
<30                  Not recommended.

Food(before/after)

Should be taken on an empty stomach. (Take on an empty stomach between meals, preferably at bedtime at least 2 hours after food, milk, milk products or Ca supplements. Mix only w/ plain water & drink immediately.)

List of Contraindications

Strontium Ranelate and Pregnancy

Information Not Available

Strontium Ranelate and Lactation

Information Not Available

Strontium Ranelate and Children

Information Not Available

Strontium Ranelate and Geriatic

Information Not Available

Strontium Ranelate and Other Contraindications

Information Not Available

Storage

Information Not Available

Lab interference

Information Not Available

Strontium Ranelate brands in India:

Renelate Stronat

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