logo image

Streptokinase information from DrugsUpdate  

See Available Brands of Streptokinase in India

P - Cautioned in pregnancy

Streptokinase(SK), a protein secreted by several species of streptococci can bind and activate human plasminogen. SK is used as an effective and inexpensive clot-dissolving medication in some cases of myocardial infarction (heart attack) and pulmonary embolism. Streptokinase belongs to a group of medications known as fibrinolytics, and complexes of streptokinase with human plasminogen can hydrolytically activate other unbound plasminogen by activating through bond cleavage to produce plasmin. There are three domains to Streptokinase, denoted α (residues 1–150), β (residues 151–287), and γ (residues 288–414). Each domain binds plasminogen, although none can activate plasminogen independently.

Pharmacodynamics

Pharmacokinetics

Streptokinase forms a complex with plasminogen which then converts plasminogen to plasmin. Plasmin breaks down clots as well as fibrinogen and other plasma proteins.

Absorption
Rapidly cleared from the circulation after IV use.

Excretion
Elimination half-life of streptokinase-activator complex: 23 minutes.

Streptokinase Indications / Streptokinase Uses

Information Not Available

Streptokinase Adverse Reactions / Streptokinase Side Effects

Fever, chills, back pain, abdominal pain, nausea, vomiting, arrhythmia, bruising, rash, pruritus, acute renal failure due to embolism and haemorrhage. Cerebral, peripheral and pulmonary embolism. Allergic reactions, liver enzyme abnormalities, hypotension.

Potentially Fatal: Haemorrhage; anaphylactic shock.

Precautions

Information Not Available

Special Precautions

Mitral stenosis associated with AF. Streptokinase treatment within last 12 months, use after prolonged or traumatic CPR; diabetic retinopathy. Elderly.

Other Drug Interactions

Antagonistic effects with antifibrinolytic agents e.g. aminocaproic acid.

Potentially Fatal: Anticoagulants, heparin, antiplatelet agents e.g. aspirin and dipyridamole affect platelet function increasing the risk of haemorrhage.

Other Interactions

Information Not Available

Dosage

Intravenous
Acute myocardial infarction
Adult: 1.5 million units as a single dose infused over 1 hour immediately after onset of symptoms.

Intravenous
Pulmonary thromboembolism
Adult: Loading dose: 250,000 units infused over 30 minutes. Maintenance: 100,000 units/hour for 24-72 hours depending on the condition to be treated. For cerebral retinal thrombosis, 12 hours may be sufficient. Monitor treatment by maintaining thrombin clotting time at 2-4 times normal values.
Child: Loading dose: 2500-4000 units/kg over 30 minutes, followed by infusion of 500-1000 units/kg/hours, continued until reperfusion occurs, up to 3 days. Initial dose may be estimated by streptokinase resistance test. Monitor treatment by maintaining thrombin clotting time at 2-4 times normal values.

Intravenous

Arteriovenous occlusions
Adult: Loading dose: 250,000 units infused over 30 minutes. Maintenance: 100,000 units/hour for 24-72 hours depending on the condition to be treated. For cerebral retinal thrombosis, 12 hours may be sufficient. Monitor treatment by maintaining thrombin clotting time at 2-4 times normal values.
Child: Loading dose: 2500-4000 units/kg over 30 minutes, followed by infusion of 500-1000 units/kg/hours, continued until reperfusion occurs, up to 3 days. Initial dose may be estimated by streptokinase resistance test. Monitor treatment by maintaining thrombin clotting time at 2-4 times normal values.

Food(before/after)

Information Not Available

List of Contraindications

Streptokinase and Pregnancy

Contraindicated in pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Streptokinase and Lactation

Information Not Available

Streptokinase and Children

Safety and efficacy not established

Streptokinase and Geriatic

Information Not Available

Streptokinase and Other Contraindications

Severe hypertension, recent stroke, cerebral neoplasm, recent history of peptic ulcer disease, ulcerative colitis, pancreatitis, subacute bacterial endocarditis, coagulation defects also due to liver or kidney disease, recent surgery, childbirth. Hypersensitivity, increased risk of cerebral bleeding, trauma. Pregnancy. Active internal bleeding, bleeding GI lesions.

Storage

Intravenous
Store unopened vials at room temperature. Reconstituted solutions should be kept in the refrigerator and used within 24 hours after preparation.

Lab interference

Intravenous
Store unopened vials at room temperature. Reconstituted solutions should be kept in the refrigerator and used within 24 hours after preparation.

© 2011-2021 DrugsUpdate.com from UPilot INC. Disclaimer | Site Map

Feedback
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to millions of Visitors instantly.
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to millions of Visitors instantly.