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Spiramycin information from DrugsUpdate  

See Available Brands of Spiramycin in India

P - Contraindicated in pregnancy
L - Caution when used during lactation

Spiramycin is a macrolide antibiotic. It is used to treat toxoplasmosis.

Spiramycin is a 16-membered ring macrolide (antibiotic). The antibacterial action involves inhibition of protein synthesis in the bacterial cell during translocation. Resistance to spiramycin can develop by several mechanisms and its prevalence is to a considerable extent proportional to the frequency of prescription in a given area.

Pharmacodynamics

Pharmacokinetics

Spiramycin is a macrolide antibacterial that inhibits protein synthesis by irreversibly binding to the 50S subunit of the ribosomal subunit thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting in stunted cell growth.

Absorption

Incompletely absorbed from the GI tract (oral); peak plasma concentrations after 1.5-3 hours.

Distribution
Widely distributed into tissues, enters breast milk. Protein binding: 10-25%.

Metabolism

Metabolised hepatically to active metabolites.

Excretion
Via bile (as metabolites), via urine (10%); 5-8 hours (elimination half-life).

Spiramycin Indications / Spiramycin Uses

Information Not Available

Spiramycin Adverse Reactions / Spiramycin Side Effects

Nausea, vomiting, abdominal pain, diarrhoea; urticaria, pruritus, macular rashes. Transient paraesthesia may occur.

Potentially Fatal: Pseudomembranous colitis; anaphylaxis; neuromuscular blockade; ventricular arrhythmias, prolongation of QT interval.

Precautions

Information Not Available

Special Precautions

Hepatic impairment; lactation. Monitor liver function. History of arrhythmias or predisposition to QT interval prolongation.

Other Drug Interactions

Decreases carbidopa absorption and levodopa concentrations. Increased risk of ventricular arrhythmias when used with astemizole, cisapride and terfenadine. Risk of acute dystonia when used with fluphenazine.

Other Interactions

Information Not Available

Dosage

Oral
Protozoal infections
Adult: 6-9 million units/day in 2-3 divided doses, increased to 15 million units/day, given in divided doses for severe infections.
Child: and neonates: Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg bid.

Oral
Toxoplasmosis
Adult: 6-9 million units/day in 2-3 divided doses, increased to 15 million units/day, given in divided doses for severe infections.
Child: and neonates: Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg bid.

Oral
Cryptosporidiosis
Adult: 6-9 million units/day in 2-3 divided doses, increased to 15 million units/day, given in divided doses for severe infections.
Child: and neonates: Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg bid.

Oral
Susceptible infections
Adult: 6-9 million units/day in 2-3 divided doses, increased to 15 million units/day, given in divided doses for severe infections.
Child: and neonates: Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg bid.

Intravenous
Toxoplasmosis
Adult: 1.5 million units by slow infusion every 8 hours, may double the dose in severe infections.

Intravenous
Susceptible infections
Adult: 1.5 million units by slow infusion every 8 hours, may double the dose in severe infections.

Intravenous

Cryptosporidiosis
Adult: 1.5 million units by slow infusion every 8 hours, may double the dose in severe infections.

Intravenous
Protozoal infections
Adult: 1.5 million units by slow infusion every 8 hours, may double the dose in severe infections.

Food(before/after)

May be taken with or without food.

List of Contraindications

Spiramycin and Pregnancy

Contraindicated in pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Spiramycin and Lactation

Caution when used during lactation

Spiramycin and Children

Information Not Available

Spiramycin and Geriatic

Information Not Available

Spiramycin and Other Contraindications

Hypersensitivity; pregnancy.

Storage

Information Not Available

Lab interference

Information Not Available

Spiramycin brands in India:

Rovamycin Forte Rovamycin RTU Toxocare

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