logo image

Somatotropin information from DrugsUpdate  

See Available Brands of Somatotropin in India

P - Caution when used during pregnancy
L - Contraindicated in lactation

Somatotropin refers to the growth hormone produced natively and naturally in animals, whereas the term somatropin refers to growth hormone produced by recombinant DNA technology, and is abbreviated "rhGH" in humans.



Somatropin is a synthetic human growth hormone of recombinant DNA origin. It stimulates skeletal and soft tissue growth by promoting cell division, amino acid uptake and protein synthesis. It also possesses both insulin-like and diabetogenic effects.

Well absorbed (SC/IM). Bioavailability ranges from 60-80%.

Renal and hepatic.

Via bile. Elimination half-life: 20-30 minutes (IV), 3-5 hours (SC/IM).

Somatotropin Indications / Somatotropin Uses

Information Not Available

Somatotropin Adverse Reactions / Somatotropin Side Effects

Hypothyroidism, peripheral oedema; headache; muscle and joint pain; benign intracranial hypertension. Loss of glycaemic control in diabetics.


Be alert for signs of acromegaly. Monitor glucose levels periodically. Routinely monitor patients with preexisting tumors or GHD secondary to an intracranial lesion for progression or recurrence of the underlying disease process. Monitor patients with a history of scoliosis for progression of the condition. Monitor standard hormonal replacement therapy closely when administering somatropin to patients with hypopituitarism. Carefully monitor patients for any malignant transformation of skin lesions. Monitor patients with Turner syndrome for CV disorders (eg, stroke). Monitor thyroid function tests and signs of respiratory infection.

Special Precautions

Monitor thyroid function; benign intracranial hypertension. DM; may require dose reduction in insulin. Pregnancy. Discontinue treatment if there is evidence of tumour growth. Monitoring in patients with scoliosis is recommended due to risk of progression of scoliosis.

Other Drug Interactions

High doses of corticosteroid may inhibit growth-promoting effects of somatropin.

Other Interactions

Information Not Available


Growth hormone deficiency
Adult: Initially, 6 mcg/kg daily. May increase gradually according to patient response. Max: 12.5 mcg/kg/day. Reassess 9 months after starting treatment.
Child: 25-35 mcg/kg daily. Reassess 9 months after starting treatment.
Elderly: Lower doses may be required.

Growth retardation due to chronic renal insufficiency
Child: 45-50 mcg/kg or 1.4 mg/m2 daily.

Turner's syndrome
Child: 45-50 mcg/kg or 1.4 mg/m2 daily.


HIV-associated wasting or cachexia
Adult: 0.1 mg/kg daily at bedtime. May be taken on alternate days for patients at increased risk of adverse effects. Max: 6 mg/day.


Prader-Will syndrome
Child: 35 mcg/kg or 1 mg/m2 daily. Max: 2.7 mg daily.


Growth retardation in children who were born small for gestational age
Child: 35 mcg/kg or 1 mg/m2 daily. Max: 2.7 mg daily.


Short bowel syndrome
Adult: 100 mcg/kg/day for 4 weeks. Max: 8 mg/day.


Children with short stature homeobox-containing (SHOX) deficiency
Child: 50 mcg/kg/day may be used.


Information Not Available

List of Contraindications

Somatotropin and Pregnancy

Caution when used during pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Somatotropin and Lactation

Contraindicated in lactation

Somatotropin and Children

Some diluents may contain benzyl alcohol, which can cause gasping syndrome in premature infants.

Safety and effectiveness in children with HIV or short bowel syndrome have not been established.

Somatotropin and Geriatic

Elderly patients may be more sensitive to the action of somatropin; therefore, start with a lower dose and smaller dose increments.

Somatotropin and Other Contraindications

Acute critical illness due to heart or abdominal surgery, multiple accidental trauma or respiratory failure; active neoplasms, proliferative or preproliferative diabetic retinopathy; lactation; patients with closed epiphyses. Intracranial lesions. Patients with Prader-Willi syndrome who are severely obese or have severe respiratory impairment.


Store at 2-8°C

Lab interference

Store at 2-8°C

Somatotropin brands in India:

Genotropin Humatrope Ig Eutropin Norditropin Nordilet

© 2011-2021 DrugsUpdate.com from UPilot INC. Disclaimer | Site Map

  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to millions of Visitors instantly.
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to millions of Visitors instantly.