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Sodium Cromoglicate information from DrugsUpdate  

See Available Brands of Sodium Cromoglicate in India

L - Caution when used during lactation

Cromoglicic acid is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate or cromolyn sodium. This drug prevents the release of inflammatory chemicals such as histamine from mast cells.

Because of their convenience (and perceived safety), leukotriene receptor antagonists have largely replaced it as the non-corticosteroid treatment of choice. Cromoglicic acid requires administration four times daily, and does not provide additive benefit in combination with inhaled corticosteroids.

Pharmacodynamics

Pharmacokinetics

Cromoglycic acid inhibits degranulation of mast cells and therefore suppresses the release of histamine, leukotrienes and slow-reacting substance of anaphylaxis.

Absorption
Oral: Poorly absorbed from the GIT with only 1% bioavailability. Inhalation: 8-10% of a dose of fine powd is deposited and rapidly absorbed from the lungs. Intranasal: < 7% of the dose is absorbed. Ophthalmic: 0.03% is absorbed.

Sodium Cromoglicate Indications / Sodium Cromoglicate Uses

Information Not Available

Sodium Cromoglicate Adverse Reactions / Sodium Cromoglicate Side Effects

Nausea, headache, dizziness, unpleasant taste, joint pain and swelling, skin rashes, aggravation of asthma, pulmonary infiltrates with eosinophilia, urticaria. Bronchospasm, wheezing, cough, nasal congestion and throat irritation following inhalation of dry powder. Intranasal use: Transient irritation of nasal mucosa. Sneezing and epistaxis (occasional). Eye drops: Transient burning and stinging.

Precautions

Information Not Available

Special Precautions

Lactation, cardiac arrhythmias, hepatic or renal dysfunction

Other Drug Interactions

Information Not Available

Other Interactions

Information Not Available

Dosage

Oral
Food allergy
Adult: 200 mg four times daily. May double the dose if effect is not satisfactory within 2-3 weeks.
Child: 100 mg four times daily. May double the dose if effect is not satisfactory within 2-3 weeks.
Max Dosage: 40 mg/kg/day.

Renal impairment: Dosage adjustment may be needed.
Hepatic impairment: Dosage adjustment may be needed.

Oral
Mastocytosis
Adult: 200 mg four times daily. May double the dose if effect is not satisfactory within 2-3 weeks.
Child: 100 mg four times daily. May double the dose if effect is not satisfactory within 2-3 weeks.
Max Dosage: 40 mg/kg/day.

Renal impairment: Dosage adjustment may be needed.
Hepatic impairment: Dosage adjustment may be needed.

Ophthalmic

Allergic conjunctivitis
Adult: Instill 2 drops of a 4% soln 4-6 times daily or apply a 4% oint bid-tid.
Elderly:

Renal impairment: Dosage adjustment may be needed.
Hepatic impairment: Dosage adjustment may be needed.

Nasal

Allergic rhinitis
Adult: 2.5 or 5 mg of a 2% or 4% soln is admin as drops or spray into each nostril 4 times daily.

Renal impairment: Dosage adjustment may be needed.
Hepatic impairment: Dosage adjustment may be needed.

Inhalation
Asthma prophylaxis
Adult: 20 mg four times daily as dry powder/nebulised solution or 10 mg four times daily as aerosol, increased to 6-8 times daily if necessary, reduced to 5 mg four times daily once asthma has been stabilised. Additional doses may be taken before exercise.
Elderly:

Renal impairment: Dosage adjustment may be needed.
Hepatic impairment: Dosage adjustment may be needed.

Food(before/after)

Information Not Available

List of Contraindications

Sodium Cromoglicate and Pregnancy

Information Not Available

Sodium Cromoglicate and Lactation

Caution when used during lactation

Sodium Cromoglicate and Children

Information Not Available

Sodium Cromoglicate and Geriatic

Information Not Available

Sodium Cromoglicate and Other Contraindications

Hypersensitivity

Storage

Inhalation
Store at 25°C

Nasal
Store at 25°C

Ophthalmic

Store at 25°C

Oral

Store at 25°C

Lab interference

Inhalation
Store at 25°C

Nasal
Store at 25°C

Ophthalmic

Store at 25°C

Oral

Store at 25°C

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