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Silver Sulfadiazine information from DrugsUpdate  

See Available Brands of Silver Sulfadiazine in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Silver sulfadiazine is a sulfa derivative topical antibacterial historically used as a topical burn cream on second- and third-degree burns. It prevents the growth of a wide array of bacteria, as well as yeast, on the damaged skin. Studies however have found that it increased healing times and is therefore no longer recommended.

Silver sulfadiazine is typically delivered in a 1% solution suspended in a water-soluble base. The chemical itself is poorly soluble, and has only very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally a problem.

Well-known proprietary brand names are Silvadene and Flamazine. The medication is also marketed under Kendall as Thermazene, with the aforementioned silvadene still functioning as a genericized trademark.



Silver sulfadiazine has broad antimicrobial activity; it is active against gram-positive and gram-negative bacteria as well as some yeasts and fungi. The silver salt acts mainly on the cell wall and membrane to disrupt its intergrity thus allowing it to impair the essential enzymes, bacterial DNA and RNA leading to cell death.


Slowly releases sulfadiazine when it comes into contact with wound exudates. Up to 10% of sulfadiazine may be absorbed.

Silver Sulfadiazine Indications / Silver Sulfadiazine Uses

Information Not Available

Silver Sulfadiazine Adverse Reactions / Silver Sulfadiazine Side Effects

Nausea, vomiting, diarrhoea; hypersensitivity, skin reactions; haematuria; crystalluria; thrombocytopenia, leucopenia, eosinophilia.

Potentially Fatal: Stevens-Johnson syndrome; agranulocytosis, jaundice, hepatitis.


Information Not Available

Special Precautions

Impaired hepatic or renal function; G6PD deficiency; maintain adequate fluid intake. Monitor blood counts. Systemic absorption, resulting in argyria may occur if it is applied to large wound areas and over prolonged periods.

Other Drug Interactions

Potentiates antidiabetic effect of sulphonylureas. Not antagonised by PABA.

Other Interactions

Information Not Available


Treatment and prophylaxis of infection in severe burns
Adult: Apply a 1% cream onto affected area once or twice daily.


Information Not Available

List of Contraindications

Silver Sulfadiazine and Pregnancy

Contraindicated in pregnancy

Silver Sulfadiazine and Lactation

Contraindicated in lactation

Silver Sulfadiazine and Children

Safety and efficacy not established

Silver Sulfadiazine and Geriatic

Information Not Available

Silver Sulfadiazine and Other Contraindications

Hypersensitivity to sulphonamides; porphyria; premature infants and infants <2 months; pregnancy and lactation.


Information Not Available

Lab interference

Information Not Available

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