Secnidazole information from DrugsUpdate  

Pharmacodynamics

Pharmacokinetics

Secnidazole is active against E histolytica, G lamblia, T vaginalis, Clostridium spp, B fragilis, Gardnerella spp. The drug enters the microorganisms by diffusion and is reduced intracellularly by low oxidation-reduction potential ferredoxin which then result in DNA damage.

Secnidazole Indications / Secnidazole Uses

Information Not Available

Secnidazole Adverse Reactions / Secnidazole Side Effects

Nausea, gastralgia, change of taste, metallic taste, stomatitis, urticaria, rashes, leucopenia. Rarely vertigo, moderate neurological, digestive disturbances.

Precautions

Information Not Available

Special Precautions

Avoid alcohol and disulfiram. Avoid in patients with history of blood disorders.

Other Drug Interactions

Concurrent disulfiram admin may cause psychotic reactions. Disulfiram-like reactions with alcohol. Cimetidine may prolong half-life.

Potentially Fatal: May potentiate anticoagulant effect of warfarin and increase risk of haemorrhage.

Other Interactions

Information Not Available

Dosage

Oral
Severe invasive amoebiasis
Adult: 1.5 g daily as single or in divided doses for 5 days.
Child: 30 mg/kg daily for 5 days.

Oral
Trichomoniasis
Adult: 2 g as a single dose.
Child: 30 mg/kg as a single dose.

Oral
Amoebiasis
Adult: 2 g as a single dose.
Child: 30 mg/kg as a single dose.

Oral
Giardiasis
Adult: 2 g as a single dose.
Child: 30 mg/kg as a single dose.

Food(before/after)

Information Not Available

Secnidazole and Pregnancy

Contraindicated in pregnancy

Secnidazole and Lactation

Contraindicated in lactation

Secnidazole and Children

Information Not Available

Secnidazole and Geriatic

Information Not Available

Secnidazole and Other Contraindications

Hypersensitivity; pregnancy (1st trimester) and lactation.

Storage

Information Not Available

Lab interference

Information Not Available