P - Contraindicated in pregnancy
L - Contraindicated in lactation
Secnidazole (brand name Flagentyl,Sindose) is a nitroimidazole anti-infective. Effectiveness in the treatment of dientamoebiasis has been reported. It has also been tested against Atopobium vaginae.
Secnidazole is active against E histolytica, G lamblia, T vaginalis, Clostridium spp, B fragilis, Gardnerella spp. The drug enters the microorganisms by diffusion and is reduced intracellularly by low oxidation-reduction potential ferredoxin which then result in DNA damage.
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Nausea, gastralgia, change of taste, metallic taste, stomatitis, urticaria, rashes, leucopenia. Rarely vertigo, moderate neurological, digestive disturbances.
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Avoid alcohol and disulfiram. Avoid in patients with history of blood disorders.
Concurrent disulfiram admin may cause psychotic reactions. Disulfiram-like reactions with alcohol. Cimetidine may prolong half-life.
Potentially Fatal: May potentiate anticoagulant effect of warfarin and increase risk of haemorrhage.
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Oral
Severe invasive amoebiasis
Adult: 1.5 g daily as single or in divided doses for 5 days.
Child: 30 mg/kg daily for 5 days.
Oral
Trichomoniasis
Adult: 2 g as a single dose.
Child: 30 mg/kg as a single dose.
Oral
Amoebiasis
Adult: 2 g as a single dose.
Child: 30 mg/kg as a single dose.
Oral
Giardiasis
Adult: 2 g as a single dose.
Child: 30 mg/kg as a single dose.
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Contraindicated in pregnancy
Contraindicated in lactation
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Hypersensitivity; pregnancy (1st trimester) and lactation.
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You will hear from us only if the bid amount matches the minimum threshold and intended usage match our vision. You can resubmit another bid.