Roxithromycin information from DrugsUpdate
Roxithromycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss. Roxithromycin is available under several brandnames, for example, Roxl-150, Roxo, Surlid, Rulide, Biaxsig, Roxar, Roximycin, Roxomycin, Tirabicin and Coroxin.
Pharmacodynamics
Pharmacokinetics
Roxithromycin inhibits protein synthesis by irreversibly binding to the 50s ribosomal subunits thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting in stunted cell growth.
Absorption
Plasma concentrations peak after 2 hours (oral); reduced if taken after food. Bioavailability: about 50%.
Distribution
Widely distributed into body tissues and fluids. Protein-binding: 96% at trough concentrations.
Metabolism
Small amounts are metabolised in the liver.
Excretion
Mainly via the faeces as unchanged drug and metabolites, via the urine (7-12%) and the lungs (15%). Elimination half-life: 8-13 hours. May be prolonged in renal and hepatic impairment, children.
Roxithromycin Indications / Roxithromycin Uses
Information Not Available
Roxithromycin Adverse Reactions / Roxithromycin Side Effects
Nausea, vomiting, abdominal pain, diarrhoea, weakness, malaise, anorexia, constipation, dyspepsia, flatulence; hepatitis; rashes, headache, dizziness, weakness, changes in blood counts; increased liver enzyme values; eosinophilia; rarely, acute pancreatitis.
Precautions
Information Not Available
Special Precautions
Hepatic impairment. Monitor liver function. Prolonged treatment increases risk of hepatotoxicity. History of arrhythmias.
Other Drug Interactions
May raise serum levels of ciclosporin and digoxin. Increased risk of rhabdomyolysis when used with simvastatin.
Other Interactions
Information Not Available
Dosage
Oral
Susceptible infections
Adult: 150 mg bid or 300 mg once daily for 5-10 days in susceptible infections.
Child: 6-40 kg: 5-8 mg/kg daily.
Renal impairment: Dosage adjustment may be required.
Hepatic impairment: Usual daily doses should be halved in hepatic impairment.
Food(before/after)
Should be taken on an empty stomach. (Take before meals.)
List of Contraindications
Roxithromycin and Pregnancy
Information Not Available
Roxithromycin and Lactation
Information Not Available
Roxithromycin and Children
Information Not Available
Roxithromycin and Geriatic
Information Not Available
Roxithromycin and Other Contraindications
Hypersensitivity. Porphyria
Storage
Information Not Available
Lab interference
Information Not Available
FOLLOW US:
