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Prochlorperazine information from DrugsUpdate  

See Available Brands of Prochlorperazine in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Prochlorperazine (Compazine, Stemzine, Buccastem, Stemetil, Phenotil) is a drug that belongs to the phenothiazine class of antipsychotic agents that are used for the antiemetic treatment of nausea and vertigo. It is also a highly-potent typical antipsychotic, 10-20x more potent than chlorpromazine.

Pharmacodynamics

Pharmacokinetics

Prochlorperazine blocks both postsynaptic dopamine receptors as well as the medullary chemo receptor trigger zone. It depresses hypothalamic and hypophyseal hormone release and posssesses α-adrenergic and anticholinergic inhibitory activity.

Prochlorperazine Indications / Prochlorperazine Uses

Information Not Available

Prochlorperazine Adverse Reactions / Prochlorperazine Side Effects

Cholestatic jaundice, cardiac arrhythmias, orthostatic hypotension, leucopaenia, thrombocytopaenia, dry mouth, blurring of vision, glaucoma, urinary retention, constipation, galactorrhoea, gynaecomastia, amenorrhoea and impotence. Buccal: Transient numbness of gum and tongue.

Potentially Fatal: Bone-marrow suppression. Cardiac arrhythmias or aspiration.

Precautions

Information Not Available

Special Precautions

Extrapyramidal syndrome, hypotension, epilepsy, impaired hepatic, renal, CV, cerebrovascular or respiratory function, glaucoma. May impair ability to drive or perform tasks requiring mental alertness or physical coordination. Parenteral use in children is not recommended. History of jaundice, parkinsonism, diabetes mellitus, hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia or urinary retention. Regular eye examinations are recommended in patients on long-term treatment.

Other Drug Interactions

Additive anticholinergic effects with antihistamines, tricyclic antidepressants and drugs used in parkinsonism. May reduce the antihypertensive effect of guanethidine and other adrenergic neurone blockers. May also increase risk of arrhythmias when used with drugs that prolong QT interval.

Potentially Fatal: Potentiation of other CNS depressants including alcohol, sedatives, hypnotics, barbiturates, opioids, antihistamines and general anaesthetics.

Other Interactions

Information Not Available

Dosage

Oral
Prophylaxis of nausea and vomitting
Adult: As maleate or mesilate: 5-10 mg bid/tid. May also be given rectally.

Oral

Nausea and vomiting
Adult: As maleate or mesilate: 20 mg, further doses are given if needed. Recommended buccal dose: As maleate: 3-6 mg bid.

Oral
Psychoses
Adult: As maleate or mesilate: 12.5 mg bid for 7 days, adjusted gradually to 75-100 mg daily according to response. Usual maintenance dose: 25-50 mg daily.
Child: 1-5 years: 1.25-2.5 mg; 5-12 years: 2.5-5 mg. May be given up to tid, if necessary.

Oral
Adjunct in severe anxiety disorders
Adult: As maleate or mesilate: 5-10 mg, up to 3-4 times daily.

Oral

Vertigo
Adult: As maleate or mesilate: 15-30 mg daily, given in divided doses. May reduce gradually to 5-10 mg daily. Recommended buccal dose: 3-6 mg bid.

Intravenous

Severe nausea and vomiting
Adult: As edisilate: 2.5-10 mg via slow IV injection or infusion at a rate not exceeding 5 mg/minute. Not to exceed 40 mg daily.

Intramuscular

Nausea and vomiting
Adult: As mesilate: 12.5 mg by deep IM. If required, may give further doses via oral admin.

Intramuscular

Psychoses
Adult: As mesilate: 12.5-25 mg by deep IM injection bid/tid.

Rectal
Nausea and vomiting
Adult: As base: 25 mg bid.

Rectal

Psychoses
Adult: As maleate: 25 mg bid/tid.

Food(before/after)

May be taken with or without food.

List of Contraindications

Prochlorperazine and Pregnancy

Contraindicated in pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Prochlorperazine and Lactation

Contraindicated in lactation

Prochlorperazine and Children

Do not prescribe for children under 9 kg or younger than 2 years of age. Do not use in pediatric surgery. Extrapyramidal adverse reactions may develop even at moderate doses. Use lowest effective dose. Some children respond with restlessness and excitement; do not give additional doses. Use with caution in children with acute illnesses or dehydration.

Prochlorperazine and Geriatic

More susceptible to effects; consider lower dose.

Prochlorperazine and Other Contraindications

CNS depression, comatose patients. Bone marrow depression, phaechromocytoma, prolactin-dependent tumours, hypersensitivity. Children <2 years. Pregnancy and lactation.

Storage

Intramuscular
Store below 30°C

Rectal
Store at 15-30°C

Lab interference

Intramuscular
Store below 30°C

Rectal
Store at 15-30°C

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