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Ebastine information from DrugsUpdate  

See Available Brands of Ebastine in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Ebastine (trade names Kestine, Evastin, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an effective block of the H1 receptor in peripheral tissue without a central side effect, i.e not causing sedation or drowsiness.

Pharmacodynamics

Pharmacokinetics

Ebastine, a piperidine derivative, is a long-acting, nonsedating, second-generation histamine receptor antagonist that binds preferentially to peripheral H1 receptors. It is metabolised to active metabolite, carebastine. It has antihistaminic, antiallergic activity and prevents histamine-induced bronchoconstriction. It does not have significant sedative or antimuscarinic actions.

Ebastine Indications / Ebastine Uses

Information Not Available

Ebastine Adverse Reactions / Ebastine Side Effects

Headache, dry mouth, drowsiness, pharyngitis, abdominal pain, dyspepsia, asthenia, epistaxis, rhinitis, sinusitis, nausea, insomnia.

Precautions

Information Not Available

Special Precautions

Caution is advised when used in hepatic impairment, renal insufficiency, QTc interval prolongation. Pregnancy, lactation.

Other Drug Interactions

Concomitant use of ketoconazole, itraconazole, clarithromycin or erythromycin may increase plasma levels of ebastine and cause QTc interval prolongation.

Other Interactions

Information Not Available

Dosage

Oral Allergic conditions Adult: 10-20 mg once daily. Child: >6 yr: 5 mg once daily.

Food(before/after)

Information Not Available

List of Contraindications

Ebastine and Pregnancy

Caution when used during pregnancy

Ebastine and Lactation

Caution when used during lactation

Ebastine and Children

Information Not Available

Ebastine and Geriatic

Information Not Available

Ebastine and Other Contraindications

Hypersensitivity, cardiac arrhythmias

Storage

Oral Store below 25 ℃

Lab interference

Oral Store below 25 ℃

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