Ebastine information from DrugsUpdate
P - Caution when used during pregnancy
L - Caution when used during lactation
Ebastine (trade names Kestine, Evastin, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an effective block of the H1 receptor in peripheral tissue without a central side effect, i.e not causing sedation or drowsiness.
Pharmacodynamics
Pharmacokinetics
Ebastine, a piperidine derivative, is a long-acting, nonsedating, second-generation histamine receptor antagonist that binds preferentially to peripheral H1 receptors. It is metabolised to active metabolite, carebastine. It has antihistaminic, antiallergic activity and prevents histamine-induced bronchoconstriction. It does not have significant sedative or antimuscarinic actions.
Ebastine Indications / Ebastine Uses
Information Not Available
Ebastine Adverse Reactions / Ebastine Side Effects
Headache, dry mouth, drowsiness, pharyngitis, abdominal pain, dyspepsia, asthenia, epistaxis, rhinitis, sinusitis, nausea, insomnia.
Precautions
Information Not Available
Special Precautions
Caution is advised when used in hepatic impairment, renal insufficiency, QTc interval prolongation. Pregnancy, lactation.
Other Drug Interactions
Concomitant use of ketoconazole, itraconazole, clarithromycin or erythromycin may increase plasma levels of ebastine and cause QTc interval prolongation.
Other Interactions
Information Not Available
Dosage
Oral Allergic conditions Adult: 10-20 mg once daily. Child: >6 yr: 5 mg once daily.
Food(before/after)
Information Not Available
List of Contraindications
Ebastine and Pregnancy
Caution when used during pregnancy
Ebastine and Lactation
Caution when used during lactation
Ebastine and Children
Information Not Available
Ebastine and Geriatic
Information Not Available
Ebastine and Other Contraindications
Hypersensitivity, cardiac arrhythmias
Storage
Oral Store below 25 ℃
Lab interference
Oral Store below 25 ℃
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