Deflazacort information from DrugsUpdate
P - Caution when used during pregnancy
L - Caution when used during lactation
FI - Food *
Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant. Deflazacort is a prodrug. Its potency is around 70?90% that of prednisone.
Pharmacodynamics
Pharmacokinetics
Deflazacort, derived from prednisolone, is a corticosteroid with mainly glucocorticoid activity. An anti-inflammatory dose of 6 mg deflazacort is equiv to 5 mg prednisolone.
Deflazacort Indications / Deflazacort Uses
Information Not Available
Deflazacort Adverse Reactions / Deflazacort Side Effects
GI disturbances, musculoskeletal, endocrine, neuropsychiatric, ophthalmic, fluid and electrolyte disturbances; susceptible to infection, impaired healing, hypersensitivity, skin atrophy, striae, telangiectasia, acne, myocardial rupture following recent MI, thromboembolism.
Precautions
Information Not Available
Special Precautions
Adrenal suppression and infection, child, adolescents, elderly, history of TB and steroid myopathy, hypertension, recent MI, CHF, liver failure, renal impairment, DM and glaucoma (including family history), osteoporosis, corneal perforation, severe affective disorders, epilepsy, peptic ulcer, hypothyroidism, pregnancy and lactation.
Other Drug Interactions
Antacids, ACE inhibitors, acetazolamide, adrenergic neuron blockers, antidiabetics, aspirin, barbiturate, β-blockers, calcium-channel blockers, carbamazepine, carbenoxolone, cardiac glycosides, clonidine, coumarins, diazoxide, diuretics, erythromycin, hydralazine, ketoconazole, methotrexate, methyldopa, mifepristone, minoxidil, moxonidine, nitrates, nitroprusside, NSAIDs, oestrogens, phenytoin, primidone, rifamycins, ritonavir, somatropin, β2 sympathomimetics, theophylline, vaccines.
Other Interactions
Food Interaction: Salad and vegetable diet including alcohol may affect anticoagulant control.
Dosage
Oral Allergic and inflammatory disorders Adult: Initially, up to 120 mg daily. Maintenance: 3-18 mg/day. Child: 0.25-1.5 mg/kg/day given on alternate days. Hepatic impairment: Dose reductions may be needed.
Food(before/after)
Information Not Available
List of Contraindications
Deflazacort and Pregnancy
Caution when used during pregnancy
Deflazacort and Lactation
Caution when used during lactation
Deflazacort and Children
Information Not Available
Deflazacort and Geriatic
Information Not Available
Deflazacort and Other Contraindications
Systemic infection; live virus vaccines in those receiving immunosuppressive doses
Storage
Information Not Available
Lab interference
Information Not Available
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