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Pindolol information from DrugsUpdate  

See Available Brands of Pindolol in India

P - Caution when used during pregnancy
L - Caution when used during lactation
LI - Lab *

Pindolol (Visken, Betapindol, Blockin L, Blocklin L, Calvisken, Cardilate, Decreten, Durapindol, Glauco-Visken, Pectobloc, Pinbetol, Prindolol, Pynastin) is a beta blocker. Pindolol is used to treat high blood pressure. It functions by relaxing blood vessels &  slowing heart rate to improve blood flow and decrease blood pressure.


Pindolol attenuates increases in heart rate, systolic blood pressure, and cardiac output resulting from exercise and isoproterenol administration, thus confirming its beta-blocking properties. The ISA or partial agonist activity of Pindolol is mediated directly at the adrenergic receptor sites and may be blocked by other beta-blockers. In catecholamine depleted animal experiments, ISA is manifested as an increase in the inotropic and chronotropic activity of the myocardium. In man, ISA is manifested by a smaller reduction in the resting heart rate (4 to 8 beats/min) than is seen with drugs lacking ISA. There is also a smaller reduction in resting cardiac output. The clinical significance of this observation has not been evaluated and there is no evidence, or reason to believe, that exercise cardiac output is less affected by Pindolol.


Pindolol is a non-cardioselective β-blocker with intrinsic sympathomimetic activity but little membrane-stabilizing properties.

Rapidly absorbed. Peak plasma concentrations within 1 hour of drug admin.

40% bound to plasma proteins. Vd in healthy adults: 2 L/kg.

Extensively metabolised.

35-40% excreted unchanged in urine. 60-65% metabolised to hydroxy-metabolites and excreted as glucuronides and ethereal sulfates.

Pindolol Indications / Pindolol Uses

Information Not Available

Pindolol Adverse Reactions / Pindolol Side Effects

Bradycardia; hypotension; heart failure, heart block; bronchospasm; fatigue; coldness of extremities; pneumonitis; pulmonary and retroperitoneal fibrosis; pleurisy; CNS effects; myopathies; GI disturbances; skin rash; pruritus; reversible alopoecia; lupus-like syndrome; male impotence; sclerosing peritonitis; paraesthesias; peripheral neuropathy; muscle cramps; haematological reactions.


Beta-blocking agents should be used with caution in patients with impaired hepatic or renal function. Poor renal function has only minor effects on Pindolol clearance, but poor hepatic function may cause blood levels of Pindolol to increase substantially.

Special Precautions

1st ° AV block. May mask symptoms of hyperthyroidism and hypoglycaemia. May unmask myasthenia gravis. May aggravate psoriasis. Abrupt withdrawal has resulted in angina, MI, ventricular arrhythmias and death. Patients on long-term treatment should discontinue medication gradually over a period of 1-2 weeks Pregnancy and lactation. Not to be used in patients with pheochromoctoma without concomitant α-adrenoceptor blocking therapy.

Other Drug Interactions

Aldesleukin and general anaesthetics may increase antihypertensive effects of β-blockers. NSAIDs may antagonise the effects of pindolol. Concurrent use with other cardiac depressants such as antiarrhythmics may precipitate bradycardia and heart block. Diabetic patients may have reduced response to insulin and oral hypoglycaemics. Concurrent use with antacids and bile-acid binding resins may reduce absorption. Increased metabolism when used with barbiturates and rifamipicin. Reduced metabolism when used with cimetidine, erythromycin, fluvoxamine and hydralazine.

Potentially Fatal: Increased risk of rebound hypertension with clonidine. (Withdraw pindolol several days before slowly withdrawing clonidine).

Other Interactions

Information Not Available


Angina pectoris
Adult: 2.5-5 mg up to tid. Max dose: 40 mg/day.

Adult: 5 mg 2-3 times daily or 15 mg once daily, increase according to patient's response. Max dose: 60 mg/day.

Adult: As a 1% eye drops.


May be taken with or without food. (May be taken w/ meals to reduce GI discomfort.)

List of Contraindications

Pindolol and Pregnancy

Caution when used during pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

In 2nd & 3rd trimesters.

Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Pindolol and Lactation

Caution when used during lactation

Pindolol and Children

Safety and efficacy not established

Pindolol and Geriatic

Information Not Available

Pindolol and Other Contraindications

2nd and 3rd ° AV block, sinus bradycardia, uncontrolled heart failure, bronchospasm or asthma, metabolic acidosis, severe peripheral arterial disease, cardiogenic shock.


Store below 30°C.

Store below 30°C.

Lab interference

Store below 30°C.

Store below 30°C.

Pindolol brands in India:


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