logo image

Nicorandil information from DrugsUpdate  

See Available Brands of Nicorandil in India

P - Caution when used during pregnancy
L - Contraindicated in lactation

Nicorandil, a vasodilator, is prescribed for the treatment and management of angina pectoris. The drug relaxes the blood vessels and alleviates the angina.


Nicorandil mediates vasodilatation by opening of potassium channels by stimulation of guanylate cyclase. Nicorandil significantly reduce preload and afterload of cardiovascular physiology and thereby improves coronary blood flow.


Nicorandil dilates arterioles and large coronary arteries by opening the potassium channels, and stimulates guanylate cyclase causing venous vasodilatation. It therefore reduces preload and afterload, and improves coronary blood flow.

Absorbed well from the GI tract (oral); peak plasma concentrations after 30-60 min.

Protein-binding: Slightly bound.



Via urine (as metabolites); 1 hour (elimination half-life).

Nicorandil Indications / Nicorandil Uses

Information Not Available

Nicorandil Adverse Reactions / Nicorandil Side Effects

Nicorandil can cause rectal bleeding, drowsiness, vomiting, skin rashes, abnormal LFTs, myalgia, stomatitis, tachycardia, hypotension, dizziness, nausea, flushing, headache and fatigue.


Nicorandil is contraindicated in patients with cardiogenic shock, hypotension and heart failure. Caution should be exercised before prescribing Nicorandil to patients with history of hypovolemia, pulmonary edema, oral ulcer, heart attack and hypotension.

Nicorandil can cause Nicorandil dizziness. Do not drive vehicles or operate heavy machineries while taking Nicorandil

Special Precautions

Hypovolaemia, low systolic BP, acute pulmonary oedema, pregnancy. May impair ability to drive or operate machinery.

Other Drug Interactions

Nicorandil may interact with anti-hypertensive drugs, vasodilators, tricyclic anti-depressants, PDE-5 inhibitors such as Sildenafil citrate.


Other Interactions

Do not consume alcohol while taking Nicorandil.


Start with initial oral dose of 10 mg of Nicorandil, twice daily. The usual recommended dose of Nicorandil is 10-20 mg, twice daily. The maximum dose should not exceed 30 mg twice daily.



Nicorandil can be taken before or after food intake

List of Contraindications

Nicorandil and Pregnancy

USFDA pregnancy category B. Nicorandil may not cause harm to an unborn foetus. Before Nicorandil treatment, the patient should discuss with the physician, if they are planning for a pregnancy.

Nicorandil and Lactation

It is unclear whether the drug could pass through the breast milk to a breast feeding baby. Consult your physician before taking Nicorandil, if you are nursing mother.

Nicorandil and Children

Nicorandil is contraindicated in children

Nicorandil and Geriatic

Information Not Available

Nicorandil and Other Contraindications

Cardiogenic shock; hypotension; left ventricular failure with low filling pressure; lactation.


Store it at room temperature.

Lab interference

Store it at room temperature.

© 2011-2023 DrugsUpdate.com. Disclaimer | Site Map

  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.