Nicorandil information from DrugsUpdate
P - Caution when used during pregnancy
L - Contraindicated in lactation
Nicorandil, a vasodilator, is prescribed for the treatment and management of angina pectoris. The drug relaxes the blood vessels and alleviates the angina.
Pharmacodynamics
Nicorandil mediates vasodilatation by opening of potassium channels by stimulation of guanylate cyclase. Nicorandil significantly reduce preload and afterload of cardiovascular physiology and thereby improves coronary blood flow.
Pharmacokinetics
Nicorandil dilates arterioles and large coronary arteries by opening the potassium channels, and stimulates guanylate cyclase causing venous vasodilatation. It therefore reduces preload and afterload, and improves coronary blood flow.
Absorption
Absorbed well from the GI tract (oral); peak plasma concentrations after 30-60 min.
Distribution
Protein-binding: Slightly bound.
Metabolism
Denitration
Excretion
Via urine (as metabolites); 1 hour (elimination half-life).
Nicorandil Indications / Nicorandil Uses
Information Not Available
Nicorandil Adverse Reactions / Nicorandil Side Effects
Nicorandil can cause rectal bleeding, drowsiness, vomiting, skin rashes, abnormal LFTs, myalgia, stomatitis, tachycardia, hypotension, dizziness, nausea, flushing, headache and fatigue.
Precautions
Nicorandil is contraindicated in patients with cardiogenic shock, hypotension and heart failure. Caution should be exercised before prescribing Nicorandil to patients with history of hypovolemia, pulmonary edema, oral ulcer, heart attack and hypotension.
Nicorandil can cause Nicorandil dizziness. Do not drive vehicles or operate heavy machineries while taking Nicorandil
Special Precautions
Hypovolaemia, low systolic BP, acute pulmonary oedema, pregnancy. May impair ability to drive or operate machinery.
Other Drug Interactions
Nicorandil may interact with anti-hypertensive drugs, vasodilators, tricyclic anti-depressants, PDE-5 inhibitors such as Sildenafil citrate.
Other Interactions
Do not consume alcohol while taking Nicorandil.
Dosage
Start with initial oral dose of 10 mg of Nicorandil, twice daily. The usual recommended dose of Nicorandil is 10-20 mg, twice daily. The maximum dose should not exceed 30 mg twice daily.
Food(before/after)
Nicorandil can be taken before or after food intake
List of Contraindications
Nicorandil and Pregnancy
USFDA pregnancy category B. Nicorandil may not cause harm to an unborn foetus. Before Nicorandil treatment, the patient should discuss with the physician, if they are planning for a pregnancy.
Nicorandil and Lactation
It is unclear whether the drug could pass through the breast milk to a breast feeding baby. Consult your physician before taking Nicorandil, if you are nursing mother.
Nicorandil and Children
Nicorandil is contraindicated in children
Nicorandil and Geriatic
Information Not Available
Nicorandil and Other Contraindications
Cardiogenic shock; hypotension; left ventricular failure with low filling pressure; lactation.
Storage
Store it at room temperature.
Lab interference
Store it at room temperature.
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