Niclosamide information from DrugsUpdate
Niclosamide (trade name Niclocide) is a teniacide ("tenia-" referring to tapeworm) in the anthelmintic family especially effective against cestodes that infect humans. It is also used as a piscicide.It is stressed that while anthelmintics are a drug family used to treat worm infections, Niclosamide is used specifically to treat tapeworms and is not effective against worms such as pinworms or roundworms. It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight. Niclosamide molecules are lethal to tapeworms upon contact.
Pharmacodynamics
Pharmacokinetics
Niclosamide is active against intestinal tapeworms. It inhibits oxidative phosphorylation in mitochondria of the worms resulting in energy depletion.
Absorption
Insignificantly absorbed from the GI tract (oral).
Niclosamide Indications / Niclosamide Uses
Information Not Available
Niclosamide Adverse Reactions / Niclosamide Side Effects
GI disturbances (e.g. nausea, retching, abdominal pain), lightheadedness, pruritus.
Precautions
The medication can have side effects such as abdominal pain, anorexia, diarrhea, and emesis. Rarely, dizziness, skin rash, drowsiness, perianal itching, and an unpleasant taste.
Special Precautions
Information Not Available
Other Drug Interactions
Possible increase in adverse effects with alcohol.
Other Interactions
Information Not Available
Dosage
Oral
Pork tapeworm infestation
Adult: 2 g as a single dose after a light breakfast.
Child: <2 years: 500 mg; 2-6 years: 1 g. All doses to be taken as a single dose after a light breakfast.
Oral
Beef or fish tapeworm infections
Adult: 1 g after breakfast and 1 g an hour later.
Child: <2 years: 250 mg after breakfast and 250 mg an hour later; 2-6 years: 500 mg after breakfast and 500 mg an hour later.
Oral
Dwarf-tapeworm infections
Adult: Initially, 2 g on the 1st day followed by 1 g daily for 6 days.
Child: <2 years: 500 mg on the 1st day followed by 250 mg daily for 6 days; 2-6 years: 1 g on the 1st day followed by 500 mg daily for 6 days.
Food(before/after)
Should be taken with food. (Take after meals.)
List of Contraindications
Niclosamide and Pregnancy
Information Not Available
Niclosamide and Lactation
Information Not Available
Niclosamide and Children
Information Not Available
Niclosamide and Geriatic
Information Not Available
Niclosamide and Other Contraindications
Hypersensitivity
Storage
Information Not Available
Lab interference
Information Not Available
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