Nicergoline information from DrugsUpdate
P - Caution when used during pregnancy
Nicergoline is an ergoloid mesylate derivative used to treat senile dementia and other disorders with vascular origins. It has been found to increase mental agility and enhance clarity and perception. It decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs.
It is used for vascular disorders such as cerebral thrombosis and atherosclerosis, arterial blockages in the limbs, Raynaud's disease, vascular migraines, and retinopathy.
Nicergoline has been registered in over fifty countries and has been used for more than three decades for the treatment of cognitive, affective, and behavioral disorders of older people.
It is marketed under the trade name Sermion.
Pharmacodynamics
Pharmacokinetics
Nicergoline is an ergot derivative. It has α-adrenergic blocking activity and produces vasodilatation.
Onset
1-1.5 hours(oral).
Absorption
Rapidly absorbed from the GI tract (oral).
Distribution
Protein-binding: 82-87%.
Metabolism
Undergoes significant 1st-pass effect.
Excretion
Via urine (80%), via faeces (20%).
Nicergoline Indications / Nicergoline Uses
Information Not Available
Nicergoline Adverse Reactions / Nicergoline Side Effects
GI disturbances; hypotension (especially after parenteral admin). Hot flushes, malaise, hyperacidity, nausea, diarrhoea, dizziness, somnolence.
Precautions
Information Not Available
Special Precautions
Porphyria. Pregnancy.
Other Drug Interactions
May potentiate action of antihypertensives. May increase cardiac depressant effects of propranolol.
Other Interactions
Information Not Available
Dosage
Oral
Mental deterioration associated with cerebrovascular insufficiency
Adult: 10 mg tid. Maintenance: 5-10 mg tid. Max: Up to 60 mg daily in divided doses.
Renal impairment: Reduce dose.
Oral
Peripheral vascular disease
Adult: 10 mg tid. Maintenance: 5-10 mg tid. Max: Up to 60 mg daily in divided doses.
Renal impairment: Reduce dose.
Intravenous
Symptoms of mental deterioration associated with cerebrovascular insufficiency
Adult: 4-8 mg by slow IV infusion (over 30 minutes).
Renal impairment: Reduce dose.
Intravenous
Peripheral vascular disease
Adult: 4-8 mg by slow IV infusion (over 30 min).
Renal impairment: Reduce dose.
Intramuscular
Symptoms of mental deterioration associated with cerebrovascular insufficiency
Adult: 2-4 mg bid.
Renal impairment: Reduce dose.
Intramuscular
Peripheral vascular disease
Adult: 2-4 mg bid.
Renal impairment: Reduce dose.
Reconstitution
Dilute in 250 ml saline solution.
Food(before/after)
Should be taken on an empty stomach. (Take on an empty stomach.)
List of Contraindications
Nicergoline and Pregnancy
Caution when used during pregnancy
Nicergoline and Lactation
Information Not Available
Nicergoline and Children
Information Not Available
Nicergoline and Geriatic
Information Not Available
Nicergoline and Other Contraindications
Information Not Available
Storage
Information Not Available
Lab interference
Information Not Available
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