Netilmicin information from DrugsUpdate  

Pharmacodynamics

Pharmacokinetics

Netilmicin, an aminoglycoside antibiotic, binds to 30S and to some extent to 50S ribosomal subunit of susceptible bacteria disrupting photosynthesis, thus rendering the bacterial cell membrane defective.

Absorption
Rapidly and completely absorbed (IM). Peak plasma concentrations after 0.5-1 hour (IM), 1 hour (IV infusion).

Excretion
Via urine within 24 hours (80% of a dose); 2-2.5 hours (elimination half-life).

Netilmicin Indications / Netilmicin Uses

Information Not Available

Netilmicin Adverse Reactions / Netilmicin Side Effects

Headache, malaise, visual disturbances, disorientation, tachycardia, hypotension, palpitations, thrombocytosis, paraesthesia, rash, chills, fever, fluid retention, vomiting, diarrhoea. Increased blood sugar; increased alkaline phosphatase; increased liver enzymes, bilirubin; increased potassium; other abnormal LFTs; decreased haemoglobin, WBCs and platelets; eosinophilia, anaemia and increase in prothrombin time.

Potentially Fatal: Nephrotoxicity; ototoxicity; anaphylaxis.

Precautions

Information Not Available

Special Precautions

Renal impairment; monitor renal, vestibular and auditory function. Monitor peak serum levels. Myasthenia gravis, parkinsonism, infant botulism; conditions predisposing to ototoxicity and nephrotoxicity. Premature and neonatal infants, dehydration, elderly. Pregnancy and lactation.

Other Drug Interactions

Information Not Available

Other Interactions

Information Not Available

Dosage

Parenteral
Susceptible infections
Adult: 4-6 mg/kg once daily or in equally divided doses given every 8 or 12 hours. Life-threatening infections: Increase to up to 7.5 mg/kg daily every 8 hours. All doses may be given as IM, slow IV (over 3-5 minutes) or as 50-200 ml infusion over 0.5-2 hours. Treatment is usually given for 7-14 days.
Child: Premature infants and neonates <1 week: 6 mg/kg daily in divided doses every 12 hours. Infants and neonates >1 week: 7.5-9 mg/kg daily in divided doses every 8 hours. Older children: 6-7.5 mg/kg daily in divided doses every 8 hours. Alternative regimen: Neonates <6 weeks: 4-6.5 mg/kg daily in divided doses every 12 hours. Older infants and children: 5.5-8 mg/kg daily in divided doses every 8 or 12 hours.
Renal impairment: Dose reduction or lengthening of interval between doses may be necessary. Haemodialysis: 50% of initial loading dose is required after dialysis.

Parenteral
Urinary tract infections
Adult: 150 mg as a single daily dose for 5 days. Complicated UTI: 3-4 mg/kg daily in divided doses every 12 hours. All doses may be given as IM, slow IV (over 3-5 minutes) or as a 50-200 ml infusion over 0.5-2 hours. Treatment is usually given for 7-14 days.
Renal impairment: Dose reduction or lengthening of interval between doses may be necessary. Haemodialysis: 50% of initial loading dose is required after dialysis.

Incompatibility
Do not mix in the same syringe with penicillins or cephalosporins.

Food(before/after)

Information Not Available

Netilmicin and Pregnancy

Caution when used during pregnancy

Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Netilmicin and Lactation

Caution when used during lactation

Netilmicin and Children

Information Not Available

Netilmicin and Geriatic

Information Not Available

Netilmicin and Other Contraindications

Hypersensitivity to the drug or other aminoglycosides

Storage

Parenteral
Store at 2-30°C. Do not freeze

Lab interference

Parenteral
Store at 2-30°C. Do not freeze