Nateglinide information from DrugsUpdate
P - Caution when used during pregnancy
L - Contraindicated in lactation
FI - Food *
Nateglinide is a drug for the treatment of type 2 diabetes. Nateglinide was developed by the Swiss pharmaceutical company Novartis.
Nateglinide belongs to the meglitinide class of blood glucose-lowering drugs.
Pharmacodynamics
Pharmacokinetics
Nateglinide, a nonsulfonylurea hypoglycaemic agent, acts by stimulating insulin release from pancreatic β-cells to reduce postprandial hyperglycaemia. This action depends on the amount of existing glucose levels.
Onset
Approx 20 minutes.
Duration
4 hours.
Absorption
Rapidly absorbed; peak plasma concentrations within 1 hour (oral).
Distribution
Protein-binding: 98%, primarily to albumin.
Metabolism
Hepatic via hydroxylation followed by glucuronidation; converted to metabolites.
Excretion
Via urine (16% unchanged drug); faeces (10%). Elimination half-life: 1.5 hours.
Nateglinide Indications / Nateglinide Uses
Information Not Available
Nateglinide Adverse Reactions / Nateglinide Side Effects
Dizziness; back pain; arthropathy; upper respiratory tract infection; flu-like symptoms; bronchitis; cough; hypoglycaemia; accidental trauma; diarrhoea.
Precautions
Information Not Available
Special Precautions
Geriatric patients, debilitated and malnourished patients; adrenal or pituitary insufficiency, moderate to severe hepatic impairment; severe renal impairment. Monitor glycaemic levels during periods of stress. Pregnancy.
Other Drug Interactions
Increased levels/effects with enzyme inhibitors (e.g. fluconazole). Increased hypoglycaemic effects with salicylates, MAOIs, nonselective β-blockers, alcohol, NSAIDs. Decreased levels/effects with enzyme inducers (e.g. rifampicin). Decreased hypoglycaemic effects with thiazide diuretics, corticosteroids, thyroid products and sympathomimetic agents.
Other Interactions
Food Interaction
Absorption delayed with food. Hypoglycaemic effects may be increased with alfalfa, aloe, bilberry, bitter melon, burdock, celery, damiana, fenugreek, garcinia, garlic, ginger, American ginseng, gymnema, marshmallow and stinging nettle. Levels/effects may be reduced with St. John's wort.
Dosage
Oral
Type 2 diabetes mellitus
Adult: 60-120 mg tid prior to each meal; may be increased to 180 mg tid if necessary.
Food(before/after)
Should be taken with food. (Take immediately before or up to ½ hour before meals.)
List of Contraindications
Nateglinide and Pregnancy
Caution when used during pregnancy
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Nateglinide and Lactation
Contraindicated in lactation
Nateglinide and Children
Safety and efficacy not established.
Nateglinide and Geriatic
No differences were observed in safety or efficacy of Nateglinide between patients age 65 and over, and those under age 65. However, greater sensitivity of some older individuals to Nateglinide therapy cannot be ruled out.
Nateglinide and Other Contraindications
Diabetic ketoacidosis; IDDM. Lactation.
Storage
Oral
Store at 25°C (77°F)
Lab interference
Oral
Store at 25°C (77°F)
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