Natamycin information from DrugsUpdate
P - Caution when used during pregnancy
L - Caution when used during lactation
Natamycin, also known as pimaricin, is a naturally occurring antifungal agent produced during fermentation by the bacterium Streptomyces natalensis, commonly found in soil. Natamycin has a very low solubility in water, due to the amphiphilic nature of the molecule. However, natamycin is effective at very low levels. Most Molds have an MIC (Minimum inhibitory concentration) of <10ppm. Natamycin is classified as a macrolide polyene antifungal and, as a drug, is used to treat fungal keratitis. It is especially effective against Aspergillus and Fusarium corneal infections. Other common members of the polyene macrolide antifungal family are Amphotericin B, Nystatin, and Filipin.
Pharmacodynamics
Pharmacokinetics
Natamycin is a polyene antifungal antibiotic which acts by increasing cell membrane permeability in susceptible fungi. It is active against Candida and Fusarium spp, and against the protozoan Trichomonas vaginalis.
Absorption
Poorly absorbed from the GI tract (<2%). Not absorbed through the skin or mucous membranes (topical). Present in therapeutic concentrations in corneal stroma but not in intraocular fluid (ocular).
Natamycin Indications / Natamycin Uses
Information Not Available
Natamycin Adverse Reactions / Natamycin Side Effects
GI disturbances (oral). Irritation (local). Conjunctival chemosis and hyperaemia (ophthalmic).
Precautions
Information Not Available
Special Precautions
Pregnancy and lactation. Porphyria
Other Drug Interactions
Ophthalmic
May increase spread of fungal eye infection when used with topical corticosteroid
Other Interactions
Information Not Available
Dosage
Oral
Intestinal candidiasis
Adult: 100 mg 4 times daily.
Child: 100 mg bid.
Oral
Oral candidiasis
Adult: One 10-mg loz every 4-6 hours.
Vaginal
Trichomoniasis
Adult: One 25-mg vaginal tablet daily for 20 days.
Vaginal
Vulvovaginal candidiasis
Adult: One 100-mg vaginal tablet for 3-6 days.
Ophthalmic
Blepharitis, conjunctivitis and keratitis
Adult: Ophthamic suspension 5%: Instil 1 drop in conjunctival sac every 1-2 hours; reduce to 1 drop 6-8 times a day after 3-4 days. Duration of treatment: 2-3 weeks. Ointment 1%: Apply bid-tid.
Topical/Cutaneous
Nail fungal infections
Adult: Apply 2% cream to the affected area once or several times a day.
Topical/Cutaneous
Skin fungal infections
Adult: Apply 2% cream to the affected area once or several times a day.
Food(before/after)
Information Not Available
List of Contraindications
Natamycin and Pregnancy
Caution when used during pregnancy
Natamycin and Lactation
Caution when used during lactation
Natamycin and Children
Safety and efficacy not established
Natamycin and Geriatic
Information Not Available
Natamycin and Other Contraindications
Hypersensitivity
Storage
Ophthalmic
Ophthalmic suspension: Store at 8-24°C (46-75°F); do not freeze.
Topical/Cutaneous
Store at 15-25°C.
Lab interference
Ophthalmic
Ophthalmic suspension: Store at 8-24°C (46-75°F); do not freeze.
Topical/Cutaneous
Store at 15-25°C.
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