Nandrolone information from DrugsUpdate
P - Contraindicated in pregnancy
L - Contraindicated in lactation
LI - Lab *
Nandrolone (19-nortestosterone) is an anabolic steroid that may be present naturally in the human body, albeit in minute quantities of less than 0.4 ng/ml. Nandrolone is most commonly sold commercially as its decanoate ester (Deca-Durabolin) and less commonly as a phenylpropionate ester (Durabolin). Nandrolone decanoate is used in the treatment of osteoporosis in postmenopausal women (though now not recommended) at a dose of 50 mg every three weeks. It is also used for some aplastic anaemias.
Pharmacodynamics
Pharmacokinetics
Nandrolone is an anabolic steroid. It promotes tissue-building processes and protein anabolism. It also stimulates erythropoeitin production, causing an increase in haemoglobin and RBC volume.
Onset
3-6 months.
Duration
Up to 30 days.
Absorption
77% (IM).
Metabolism
Hepatic.
Excretion
Via urine.
Nandrolone Indications / Nandrolone Uses
Information Not Available
Nandrolone Adverse Reactions / Nandrolone Side Effects
Male: Postpubertal: Acne, gynaecomastia, bladder irritability, priapism, insomnia, chills, decreased libido, hepatic dysfunction, nausea, diarrhoea, prostatic hyperplasia. Prepubertal: Acne, virilism, chills, insomnia, hyperpigmentation, diarrhoea, nausea. Female: Virilism, hypercalcaemia, nausea, diarrhoea, chills, insomnia, iron deficiency anaemia, hepatic dysfunction.
Precautions
Women should be observed for signs of virilization (deepening of the voice, hirsutism, acne, clitorimegaly and menstrual irregularities). Discontinuation of drug therapy at the time of evidence of mild virilism is necessary to prevent irreversible virilization. Such virilization is usual following anabolic steroid use in high doses.
The insulin or oral hypoglycemic dosage may need adjustment in diabetic patients who receive anabolic steroids.
Special Precautions
Monitor diabetic patients carefully. Conditions influenced by oedema (e.g. CV disease, migraine, seizure disorder, renal impairment). Hepatic impairment. Elderly. Discontinue if signs of virilisation in women occur. Monitor skeletal maturation in children.
Other Drug Interactions
May increase effects of oral anticoagulants, insulin, oral antidiabetic agents, adrenal steroid, adrenocorticotropic hormone (ACTH).
Other Interactions
Information Not Available
Dosage
Intramuscular
As anabolic after debilitating illness
Adult: As decanoate: 25-100 mg once every 3-4 weeks.
Intramuscular
Postmenopausal osteoporosis
Adult: As decanoate: 25-100 mg once every 3-4 weeks.
Intramuscular
Metastatic breast cancer
Adult: As decanoate: 25-100 mg once every 3-4 weeks.
Intramuscular
Anaemia of chronic renal failure
Adult: As decanoate: 50-200 mg weekly.
Intramuscular
Anaemia in chemotherapy patients
Adult: 50-150 mg weekly.
Food(before/after)
Information Not Available
List of Contraindications
Nandrolone and Pregnancy
Contraindicated in pregnancy
Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.
Nandrolone and Lactation
Contraindicated in lactation
Nandrolone and Children
The safety and efficacy of Nandrolone decanoate in children with metastatic breast cancer (rarely found) has not been established. Anabolic agents may accelerate epiphyseal maturation more rapidly than linear growth in children, and the effect may continue for six months after the drug has been stopped. Therefore, therapy should be monitored by X-ray studies at six month intervals in order to avoid the risk of compromising the adult height.
Nandrolone and Geriatic
Information Not Available
Nandrolone and Other Contraindications
Prostatic or breast carcinoma (male); nephrosis, porphyria; infants, pregnancy and lactation.
Storage
Information Not Available
Lab interference
Information Not Available
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