Mometasone information from DrugsUpdate
P - Caution when used during pregnancy
L - Caution when used during lactation
Mometasone furoate (also referred to as mometasone) is a glucocorticoid steroid used topically to reduce inflammation of the skin or in the airways.
Pharmacodynamics
Pharmacokinetics
Mometasone depresses the formation, release and activity of endogenous inflammatory chemical mediators (e.g. kinins, histamine, liposomal enzymes and prostaglandin). It inhibits the margination and subsequent cell migration to the injury site, reverses vascular dilatation and permeability, resulting in decreased access of cells to the area of injury.
Absorption
Ointment: 0.7%; increased with occlusive dressings. Nasal spray: Undetectable in plasma. Oral inhalation: <1%.
Distribution
Protein-binding: 98-99%.
Metabolism
Hepatic.
Excretion
Via faeces, bile, urine.
Mometasone Indications / Mometasone Uses
Information Not Available
Mometasone Adverse Reactions / Mometasone Side Effects
Nasal/Oral inhalation: Headache, fatigue, depression; musculoskeletal pain, arthalgia; sinusitis, rhinitis, upper respiratory infection, pharyngitis, cough, epistaxis; viral infection, nasal and oral candidiasis; chest pain; abdominal pain, dry throat, vomiting, diarrhoea, dyspepsia, flatulence, gastroenteritis, nausea, vomiting; dysmenorrhoea; back pain, myalgia; conjunctivitis; earache, otitis media; asthma, bronchitis, dysphonia; nasal irritation, burning and septal perforation; wheezing; nasal ulcers; growth suppression. Topical: Bacterial skin infection, burning, furunculosis, pruritus, skin atrophy, tingling/stinging, folliculitis, moniliasis, paraesthesia, skin depigmentation, rosacea, cataract, growth suppression.
Potentially Fatal: Adrenal suppression, immunosuppression, Kaposi's sarcoma in prolonged periods, anaphylaxis.
Precautions
Monitor
Because nasal and inhaled corticosteroids have been associated with glaucoma and cataracts, closely follow patients with changes in vision and a history of glaucoma and/or cataracts. Monitor growth and development of children on prolonged therapy.
Overdosage
Systemic corticosteroid effects.
Special Precautions
Discontinue if irritation or sensitisation occurs. Systemic absorption increases when area of application is extensive or an occlusive dressing is used. Pregnancy and lactation. DM, hepatic and renal diseases, myasthenia gravis, CV disease, ocular diseases, osteoporosis, GI diseases, history of seizure disorders. Not for status asthmaticus or relief of acute bronchospasm. Requires dosage adjustments with thyroid status. May reduce growth velocity in children; monitor growth. Taper withdrawal.
Other Drug Interactions
Increased risk of hypokalaemia with amphotericin B, potassium-wasting diuretics. Decreases hypoglycaemic effects of antidiabetic drugs. Increased serum levels with antifungals (imidazole). Increased risk of tendinopathies with fluoroquinolones.
Other Interactions
Information Not Available
Dosage
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.1% cream/ointment/lotion: Apply onto the affected areas as directed.
Child: Cream/Ointment: ≥2 years: Apply thin film to affected area once daily. Do not use for > 3 weeks. Lotion: ≥12 years: Apply a few drops to affected area once daily.
Nasal
Treatment and prophylaxis of allergic rhinitis
Adult: 100 mcg in each nostril once daily, increased to 200 mcg into each nostril once daily if needed. Maintenance: 50 mcg in each nostril daily.
Child: 2-11 years: 50 mcg in each nostril daily; ≥12 years: 100 mcg in each nostril daily.
Nasal
Nasal polyps
Adult: 100 mcg in each nostril once daily; may increase to bid after 5-6 weeks if needed.
Inhalation
Asthma prophylaxis
Adult: Mild to moderate: Initially, 400 mcg once daily in the evening. Maintenance: 200 mcg once to bid. Severe: Initially, 400 mcg bid, then titrated to lowest effective dose once controlled.
Child: Mild to moderate: Initially, 400 mcg once daily. Maintenance: 200 mcg once to bid. Severe: Initially, 400 mcg bid, then titrated to lowest effective dose once controlled.
Food(before/after)
Information Not Available
List of Contraindications
Mometasone and Pregnancy
Caution when used during pregnancy
Mometasone and Lactation
Caution when used during lactation
Mometasone and Children
May be more susceptible to topical corticosteroid–induced HPA axis suppression and Cushing syndrome. Children may be more susceptible to corticosteroid-induced HPA suppression.
Mometasone and Geriatic
No difference in safety and efficacy have been noted in patients 65 years of age and older compared with younger patients.
Mometasone and Other Contraindications
Information Not Available
Storage
Inhalation
Store at 15-30°C. Discard when counter reads "0" or 45 days after opening.
Nasal
Store at 15-30°C. Protect from light.
Topical/Cutaneous
Cream: Store at 2-25°C.
Lotion
Store at 2-30°C.
Ointment
Store at 15-30°C.
Lab interference
Inhalation
Store at 15-30°C. Discard when counter reads "0" or 45 days after opening.
Nasal
Store at 15-30°C. Protect from light.
Topical/Cutaneous
Cream: Store at 2-25°C.
Lotion
Store at 2-30°C.
Ointment
Store at 15-30°C.
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