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Melatonin information from DrugsUpdate  

See Available Brands of Melatonin in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Melatonin, also known chemically as N-acetyl-5-methoxytryptamine, is a naturally occurring compound found in animals, plants, and microbes.In animals, circulating levels of melatonin vary in a daily cycle, thereby regulating the circadian rhythms of several biological functions.Many biological effects of melatonin are produced through activation of melatonin receptors, while others are due to its role as a pervasive and powerful antioxidant, with a particular role in the protection of nuclear and mitochondrial DNA.

Melatonin in plants has multiple roles, including regulation of the photoperiod, in plant defence responses, and as a scavenger of reactive oxygen species.

Products containing melatonin have been available as a dietary supplement in the United States since 1993. Over-the-counter sales of the hormone remain illegal in many other countries, and the U.S. Postal Service lists melatonin among items prohibited by Germany.

Foods may contain trace amounts of melatonin, but no food has been found to elevate plasma melatonin levels.

Pharmacodynamics

Pharmacokinetics

Melatonin is the hormone secreted by the pineal gland. In humans, the plasma levels of melatonin are high at night and low during the day and it appears to have a role in circardian rhythm regulation. This action of melotonin finds a possible place in the management of jet lag and other sleep disorders. Melatonin is also being used in the treatment of cluster headaches.

Melatonin Indications / Melatonin Uses

Information Not Available

Melatonin Adverse Reactions / Melatonin Side Effects

Increased seizure activity; drowsiness, headache. Disruption of normal circadian rhythm. May worsen symptoms for individuals with depression.

Precautions

Information Not Available

Special Precautions

May impair ability to drive or operate machinery. Epilepsy

Other Drug Interactions

Information Not Available

Other Interactions

Information Not Available

Dosage

Oral
Disturbed biorhythms, Sleep disorders
Adult: Usual dose 3-6 mg at bedtime.
Child: 2-3 mg at bedtime, increased after 1-2 weeks to 4-6 mg if needed. Max dose 10 mg.

Food(before/after)

Information Not Available

List of Contraindications

Melatonin and Pregnancy

Contraindicated in pregnancy

Melatonin and Lactation

Contraindicated in lactation

Melatonin and Children

Information Not Available

Melatonin and Geriatic

Information Not Available

Melatonin and Other Contraindications

Pregnancy and lactation

Storage

Information Not Available

Lab interference

Information Not Available

Melatonin brands in India:

Meloset Zytonin

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