Lornoxicam information from DrugsUpdate
P - Contraindicated in pregnancy
L - Contraindicated in lactation
Lornoxicam (chlortenoxicam) is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and antipyretic properties. It is available in oral and parenteral formulations.
Pharmacodynamics
Pharmacokinetics
Lornoxicam is an NSAID that is used in musculoskeletal, joint disorders and other painful conditions including postoperative pain. Lornoxicam is a potent inhibitor of both COX-1 and COX-2 enzymes.
Absorption
Extensively absorbed from the GI tract. Peak plasma concentration within 1-2 hours (oral) or 25 min (IM).
Distribution
99% bound to plasma proteins.
Metabolism
Metabolised to its inactive metabolite.
Excretion
Excreted in the faeces (as metabolites) and urine (as unchanged drug). Mean elimination half life of 3-4 hours.
Lornoxicam Indications / Lornoxicam Uses
Information Not Available
Lornoxicam Adverse Reactions / Lornoxicam Side Effects
Abdominal pain, diarrhoea, dizziness, dyspepsia, nausea, vomiting; headache; haematologic disorders; CNS effects; visual disturbance; tinnitus; nephrotoxicity; fluid retention; photosensitivity; alveolitis; pancreatitis; Stevens-Johnson syndrome; toxic epidermal necrolysis; colitis induction/exacerbation; stomatitis; hypertension, palpitation; insomnia, somnolence.
Precautions
Information Not Available
Special Precautions
Active infections; asthma; allergic disorders; haemorrhagic disorders; hypertension; impaired renal, hepatic, cardiac function.
Other Drug Interactions
Increased lornoxicam blood conc when given concomitantly with cimetidine.Enhanced effects of anticoagulants, sulfonylureas, methotrexate, ciclosporin, digoxin. Decreased effects of diuretics, ACE inhibitors.
Potentially Fatal: Increased risk of lithium toxicity.
Other Interactions
Information Not Available
Dosage
Oral
Pain relief
Adult: 8-16 mg daily. Max: 24 mg daily.
Oral
Osteoarthritis
Adult: 12 mg daily in 2-3 divided doses, up to 16 mg daily if needed.
Oral
Rheumatoid arthritis
Adult: 12 mg daily in 2-3 divided doses, up to 16 mg daily if needed.
Parenteral
Pain relief
Adult: 8 mg once or twice daily by IM/IV inj. Max: 24 mg daily.
Food(before/after)
Information Not Available
List of Contraindications
Lornoxicam and Pregnancy
Contraindicated in pregnancy
Lornoxicam and Lactation
Contraindicated in lactation
Lornoxicam and Children
Information Not Available
Lornoxicam and Geriatic
Information Not Available
Lornoxicam and Other Contraindications
Patients with peptic ulceration; severe renal impairment; pregnancy and lactation.
Storage
Information Not Available
Lab interference
Information Not Available
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