Benzocaine information from DrugsUpdate
P - Caution when used during pregnancy
LI - Lab *
Benzocaine is a local anesthetic commonly used as a topical pain reliever. It is the active ingredient in many over-the-counter anesthetic ointments (e.g. products for oral ulcers of Anbesol by Wyeth, Kank+a by Blistex, Orabase B and Orajel by Del Pharmaceuticals, and Ultracare by Ultradent). It is also combined with antipyrine to form A/B Otic Drops, (Brand name Auralgan) to relieve earpain and remove cerumen.
Pharmacodynamics
Pharmacokinetics
Benzocaine is a local anaesthetic which acts by preventing the generation and transmission of impulses along nerve fibers and at nerve endings. Depolarisation and ion-exchange are inhibited. In general, loss of pain occurs before loss of sensory, autonomic and motor functions. Onset 1 min. Duration 15-20 min
Benzocaine Indications / Benzocaine Uses
Information Not Available
Benzocaine Adverse Reactions / Benzocaine Side Effects
Hypersensitivity reactions; vertigo; nystagmus; sensitization. CNS excitation; tinnitus; blurred vision; nausea and vomiting; muscle twitching and tremors; convulsions. Numbness of tongue and perioral region; drowsiness. CVS effects; angioedema; contact dermatitis; burning and stinging effects.
Precautions
Information Not Available
Special Precautions
Elderly, debilitated, child. Epilepsy, impaired cardiac conduction or resp function, shock or hepatic impairment. Myasthenia gravis. Avoid: Contact with middle ear; prolonged use or application on extensive areas of the skin. Avoid eating or drinking for at least 3-4 hr after the anaesthetic; rubbing or touching the eye while anaesthesia persists. The anaesthetised eye should be protected from dust and bacterial contamination. Chemical burns must be neutralised before treatment with benzocaine. Pregnancy.
Other Drug Interactions
Antagonism with sulfonamides; aminosalicylic acid; anticholinesterases; suxamethonium; antiarrhythmics; MAOIs; TCAs.
Other Interactions
Information Not Available
Dosage
Topical/Cutaneous Topical analgesia and anaesthesia Adult: As gel, paste, cream, lotion, spray, solution or suppository up to 20%: Apply to affected area as directed. Elderly: May require lower doses. Mouth/Throat Sore throat Adult: Up to 10 mg lozenge may be dissolved slowly in the mouth and repeated every 2 hr as necessary. Child: Not recommended for child under 3 yr old. Elderly: May require lower doses. Mouth/Throa.
Surface anaesthesia of mouth and throat Adult: As gel, paste, spray or solution up to 20%: Apply to affected area up to 4 times daily. Elderly: May require lower doses.
Food(before/after)
Information Not Available
List of Contraindications
Benzocaine and Pregnancy
Caution when used during pregnancy Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Benzocaine and Lactation
Information Not Available
Benzocaine and Children
Information Not Available
Benzocaine and Geriatic
Information Not Available
Benzocaine and Other Contraindications
Hypersensitivity. Complete heart block. Low plasma-cholinesterase concentrations. Pyrogenic infection at or near the skin. Inj into or application to inflamed, infected tissues, to damaged skin mucosa or on perforated tympanic membrane.
Storage
Information Not Available
Lab interference
Information Not Available
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