logo image

Irbesartan information from DrugsUpdate  

See Available Brands of Irbesartan in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Irbesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Irbesartan was developed by Sanofi Research (now part of sanofi-aventis). It is jointly marketed by sanofi-aventis and Bristol-Myers Squibb under the trade names Aprovel, Karvea, and Avapro.



Irbesartan is an angiotensin II type I receptor antagonist and therefore blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II.


Rapidly absorbed from the GIT (oral); peak plasma concentrations are achieved after 1.5-2 hours.

Protein-binding around 96%

Some hepatic metabolism via cytochrome P450 isoenzyme CYP2C9 to inactive metabolites.

Via bile and urine (as unchanged drug and metabolites); via urine (20% of IV dose, <2% as unchanged). 11-15 hours (elimination half-life).

Irbesartan Indications / Irbesartan Uses

Information Not Available

Irbesartan Adverse Reactions / Irbesartan Side Effects

Diarrhoea, dizziness, fatigue, headache, hyperkalaemia. Dyspepsia, oedema, myalgia, insomnia, nasal congestion, 1st dose orthostatic hypotension, rash, pharyngitis, urticaria, angioedema, anxiety/nervousness, tachycardia.


Renal Function
Use with caution in patients whose renal function may depend on the activity of the renin-angiotensin-aldosterone system (eg, patients with severe CHF); use may be associated with oliguria, progressive azotemia, acute renal failure, and death.

Initiation of antihypertensive therapy may cause symptomatic hypotension in patients with intravascular volume or sodium-depletion.

Special Precautions

Child <6 years. Unilateral or bilateral renal artery stenosis; vol or Na depletion; aortic or mitral valve stenosis, hypertrophic cardiomyopathy.

Other Drug Interactions

Potassium or potassium-sparing diuretics may increase risk of hyperkalaemia. NSAIDs may reduce antihypertensive response. Excretion of lithium may be reduced, monitor lithium concentrations.

Other Interactions

Information Not Available


Adult: 150 mg once daily, increased to 300 mg once daily if necessary. For patients with intravascular volume depletion: Initially, 75 mg once daily.
Child: 6-16 years: 75 mg once daily increased to 150 mg if necessary.
Elderly: >75 years: Initially 75 mg once daily.
Renal impairment: Haemodialysis: Initially, 75 mg once daily.

Diabetic nephropathy in Type 2 diabetes mellitus
Adult: 150 mg once daily, increased to 300 mg once daily if necessary.


May be taken with or without food.

List of Contraindications

Irbesartan and Pregnancy

Contraindicated in pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

In 2nd & 3rd trimesters.
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Irbesartan and Lactation

Contraindicated in lactation

Irbesartan and Children

Safety and efficacy not established in children younger than 6 years of age.

Irbesartan and Geriatic

Information Not Available

Irbesartan and Other Contraindications

Hypersensitivity; pregnancy and lactation


Information Not Available

Lab interference

Information Not Available

Irbesartan brands in India:

Aprovel Coaprovel Irbest Irovel Irovel-H Xarb Xarb-H

© 2011-2023 DrugsUpdate.com. Disclaimer | Site Map

  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.