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Indinavir information from DrugsUpdate  

See Available Brands of Indinavir in India

P - Caution when used during pregnancy
L - Caution when used during lactation
FI - Food *

Indinavir (IDV; trade name Crixivan, manufactured by Merck) is a protease inhibitor used as a component of highly active antiretroviral therapy (HAART) to treat HIV infection and AIDS.



Indinavir binds reversibly to HIV-protease which prevents cleavage of the viral precursor polyproteins. As a result, immature viral particles incapable of infecting other cells are formed.

Absorbed rapidly from the GIT (oral); peak plasma concentrations after 0.8 hours. May be reduced by intake of high-calorie meals.

Protein-binding: 60%

Oxidation by CYP3A4 and glucuronidation.

Via urine (<20%, half as unchanged drug), via faeces (remaining dose); 1.8 hours (elimination half-life).

Indinavir Indications / Indinavir Uses

Information Not Available

Indinavir Adverse Reactions / Indinavir Side Effects

Flank pain, abdominal pain, nephrolithiasis, malaise, nausea, vomiting, diarrhoea, elevated liver enzymes, hyperbilirubinaemia, raised creatinine phosphokinase and blood lipids, back pain, lipodystrophy, alopecia, acid regurgitation, dyspepsia, dry mouth, dysuria, dry skin, hyperpigmentation, headache, dizziness, somnolence, cough, dyspnoea.

Potentially Fatal: Acute haemolytic anemia; acute hepatitis.


Information Not Available

Special Precautions

Increased risk of urolithiasis/nephrolithiasis. Ensure adequate hydration. Hyperbilirubinaemia may be exacerbated. Diabetes; haemophilia. Monitor for signs of lipodystrophy. Pregnancy and lactation.

Other Drug Interactions

Reduced absorption with antacids. Increased concentrations with ketoconazole, delavirdine, nelfinavir and ritonavir. Reduced efficacy with nevirapine, efavirenz or rifampicin. Increased risk of myopathy with statins. Increased concentrations of phosphodiesterase-5 inhibitors.

Potentially Fatal: Increased risk of cardiac arrhythmias with amiodarone, pimozide or cisapride. Increased sedation and respiratory depression with midazolam, alprazolam and triazolam. Increased risk of ergotism with ergot derivatives. Increased toxicity of drugs with narrow therapeutic index.

Other Interactions

Food Interaction
Reduced concentrations with grapefruit juice. Reduced antiviral response with St. John's wort.


HIV infection
Adult: 800 mg every 8 hours. Dose reduction may be required when used with delavirdine, itraconazole, ketoconazole and rifabutin.
Child: >4 years: 500 mg/m2 every 8 hours without exceeding adult dose.
Hepatic impairment: Mild-moderate (due to cirrhosis): 600 mg every 8 hours.


Information Not Available

List of Contraindications

Indinavir and Pregnancy

Caution when used during pregnancy

Indinavir and Lactation

Caution when used during lactation

Indinavir and Children

Safety and efficacy not established.

Indinavir and Geriatic

Dose selection should be cautious, reflecting greater frequency of decreased hepatic, renal, or cardiac function.

Indinavir and Other Contraindications

Hypersensitivity. Severe hepatic impairment.


Store at 15-30°C (59-86°F).

Lab interference

Store at 15-30°C (59-86°F).

Indinavir brands in India:

Inbec Inbed Ind Indease Indivan Indivir Virodin

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