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Indapamide information from DrugsUpdate  

See Available Brands of Indapamide in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Indapamide is a non-thiazide sulphonamide diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated cardiac failure. The US trade name for indapamide is Lozol. Indapamide is marketed as Natrilix outside of the US. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.

It is described as a thiazide-like diuretic.



Indapamide enhances excretion of sodium, chloride and water by interfering with the transport of sodium ions across the renal tubular epithelium.

Rapidly and completely absorbed from the GI tract (oral). Peak plasma levels are achieved within 2-2.5 hours.

Widely distributed, preferentially and reversibly bound to erythrocytes.

Extensively metabolised in the liver.

Via urine (60-70% as metabolites, 5-7% as unchanged), via faeces (16-23% remaining dose); 14 hours (elimination half-life).

Indapamide Indications / Indapamide Uses

Information Not Available

Indapamide Adverse Reactions / Indapamide Side Effects

Headache, dizziness, weakness, drowsiness, fatigue, agitation, nervousness, anorexia, nausea, vomiting, pain, diarrhoea, constipation, orthostatic hypotension, palpitations, hypokalaemia, hyponatraemia, metabolic alkalosis.


Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or a sensitivity to hypokalemia and in patients with gout.

Nausea, vomiting, weakness, GI disorders, electrolyte imbalance. In severe cases, hypotension and respiratory depression. Stomach emptying recommended.

Special Precautions

Pregnancy, lactation, elderly, renal impairment, fluid or electrolyte imbalance, hyperuricaemia, DM, lupus erythematosus.

Other Drug Interactions

Additive effect with other antihypertensive agents and diuretics. Increased chance of hypokalaemia with corticosteroids, corticotropin and amphotericin.

Potentially Fatal: Increased risk of lithium toxicity. Hypokalaemia enhances digitalis toxicity with cardiac gycosides.

Other Interactions

Information Not Available


Adult: 1.25-2.5 mg once daily, alone or in conjunction with other antihypertensives.

Adult: 2.5 mg once daily increased to 5 mg daily after 1 weeks if needed.


Should be taken with food.

List of Contraindications

Indapamide and Pregnancy

Caution when used during pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

If used in pregnancy-induced hypertension:

Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Indapamide and Lactation

Caution when used during lactation

Indapamide and Children

Safety and effectiveness of Indapamide in pediatric patients have not been established.

Indapamide and Geriatic

Information Not Available

Indapamide and Other Contraindications

Anuria, severe hepatic impairment


Store at 20-25°C.

Lab interference

Store at 20-25°C.

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