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Hyoscine information from DrugsUpdate  

See Available Brands of Hyoscine in India

P - Caution when used during pregnancy
L - Caution when used during lactation
LI - Lab *

An alkaloid found with hyoscyamine (with which it is also isomeric) in henbane, and extracted as a white, amorphous, semisolid substance.

Pharmacodynamics

Pharmacokinetics

Hyoscine competitively blocks muscarinic receptors and has central and peripheral actions. It relaxes smooth muscle and reduces gastric and intestinal motility.

Onset
Oral, IM: 0.5-1 hours; IV: 10 min.

Duration
Oral, IM: 4-6 hours; IV: 2 hours

Absorption
Tertiary salts: Readily absorbed. Quaternary salts: Poorly absorbed.

Distribution
Reversibly bound to plasma proteins.

Metabolism
Hepatic.

Excretion
Via urine (as metabolites); 4.8 hours (elimination half-life).

Hyoscine Indications / Hyoscine Uses

Information Not Available

Hyoscine Adverse Reactions / Hyoscine Side Effects

Flushing, postural hypotension, tachycardia, fibrillation. Rarely psychotic reactions. Dizziness, drowsiness, fatigue, headache, memory loss. Dry skin, erythema, increased sensitivity to light, rash. Bloatedness, constipation, dry throat, dysphagia, nausea, vomiting, xerostomia. Dysuria, urinary retention. Tremor, weakness. Impaired accommodation, blurred vision, cycloplegia, dryness, narrow-angle glaucoma, increased intraocular pain, itching, photophobia, pupil dilation. Dry nose. Decreased diaphoresis, heat intolerance. Ophthalmic: Somnolence, dermatitis, oedema, exudate, follicular conjunctivitis, increased IOP, local irritation, photophobia, vascular and respiratory congestion.

Potentially Fatal: CNS depression, coma, circulatory and respiratory failure.

Precautions

Information Not Available

Special Precautions

Hepatic/renal disease, pyloric stenosis, urinary retention, prostatic hyperplasia, psychosis, seizure disorders, ulcerative colitis, coronary artery disease, tachyarrhythmias, heart failure, hypertension. Elderly, children, pregnancy, lactation.

Other Drug Interactions

Additive sedative effects with alcohol or other CNS depressants. Reduced effects with acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine, tacrine).

Potentially Fatal: Effect potentiated by other anticholinergic drugs and TCAs.

Other Interactions

Information Not Available

Dosage

Oral
Gastrointestinal tract spasm
Adult: As butylbromide: 20 mg 4 times daily.
Child: As butylbromide: 6-12 years: 10 mg tid.

Oral

Genitourinary spasm
Adult: As butylbromide: 20 mg 4 times daily.
Child: As butylbromide: 6-12 years: 10 mg tid.

Oral
Prophylaxis of motion sickness
Adult: As hydrobromide: 300 mcg 30 min before a journey, then 300 mcg every 6 hours if required. Max: 3 doses in 24 hours.

Child: As hydrobromide: 3-4 years: 75 mcg 20 min before a journey, repeated if needed. Max dose: 150 mcg in 24 hr. 4-10 years: 75-150 mcg, >10 years: 150-300 mcg.
Max Dosage: 3 doses in 24 hours.

Subcutaneous

Prophylaxis of nausea and vomitting
Adult: As hydrobromide: 0.3-0.6 mg.
Child: As hydrobromide: 0.006 mg/kg.

Subcutaneous

Preoperative sedation
Adult: As hydrobromide: 0.6 mg 3-4 times daily.

Parenteral
Gastrointestinal tract spasm
Adult: As butylbromide: 20 mg IM/IV repeated after 30 minute if needed. Max: 100 mg daily.
Max Dosage: 100 mg daily.

Parenteral
Genitourinary spasm
Adult: As butylbromide: 20 mg IM/IV repeated after 30 min if needed. Max: 100 mg daily.
Max Dosage: 100 mg daily.

Parenteral
Premedication before anaesthesia
Adult: As hydrobromide: 0.2-0.6 mg via SC or IM injection 30-60 minutes before induction of anesthesia
Child: As hydrobromide: 15 mcg/kg via SC or IM injection, 30-60 minutes before induction of anesthesia

Transdermal
Prophylaxis of motion sickness
Adult: As patch delivering 1 mg over 3 days: Apply 1 patch at least 4 hours before exposure to motion. To be applied behind the ear.

Ophthalmic
Mydriasis and cycloplegia for refraction
Adult: As hydrobromide: Instil 1-2 drops of 0.25% soln to eye(s) 1 hours before procedure.
Child: As hydrobromide: Instil 1 drop of 0.25% soln to eye(s) bid for 2 days before procedure.

Ophthalmic
Iridocyclitis
Adult: As hydrobromide: Instil 1-2 drops of 0.25% solution to eye(s) up to 4 times daily.
Child: As hydrobromide: Instil 1 drop of 0.25% soln to eye(s) up to tid.

Food(before/after)

Information Not Available

List of Contraindications

Hyoscine and Pregnancy

Caution when used during pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Hyoscine and Lactation

Caution when used during lactation 

Hyoscine and Children

Information Not Available

Hyoscine and Geriatic

Information Not Available

Hyoscine and Other Contraindications

Narrow-angle glaucoma, acute haemorrhage, paralytic ileus, tachycardia due to cardiac insufficiency, myasthenia gravis.

Storage

Ophthalmic
Store at 8-27°C (46-80°F).

Oral
Store at room temperature of 15-30°C (58-86°F).

Parenteral
Store at room temperature of 15-30°C (58-86°F).

Subcutaneous
Store at room temperature of 15-30°C (58-86°F).

Transdermal
Store at 20-25°C (68-77°F).

Lab interference

Ophthalmic
Store at 8-27°C (46-80°F).

Oral
Store at room temperature of 15-30°C (58-86°F).

Parenteral
Store at room temperature of 15-30°C (58-86°F).

Subcutaneous
Store at room temperature of 15-30°C (58-86°F).

Transdermal
Store at 20-25°C (68-77°F).

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