Hydro-Chlorothiazide information from DrugsUpdate
P - Contraindicated in pregnancy
L - Contraindicated in lactation
LI - Lab *
Information Not Available
Pharmacodynamics
Pharmacokinetics
Information Not Available
Hydro-Chlorothiazide Indications / Hydro-Chlorothiazide Uses
Information Not Available
Hydro-Chlorothiazide Adverse Reactions / Hydro-Chlorothiazide Side Effects
Volume depletion& electrolyte imbalance, dry mouth, thirst, lethargy, drowsiness, muscle pain, & cramps, hypotension, hypersensitivity reactions e.g. rashes, photosensitivity, thrombocytopenia, jaundice, pancreatitis, fatigue, weakness may preciptate an attack of gout; impotence, hyperglycaemia, anorxia, gastric irritation, nausea, vomiting, constiption, diarrhoea, sialadenitis, dizziness, raised Ca concentration. Hypersensitivity reactions.
Precautions
Information Not Available
Special Precautions
Existing electrolyte disturbances, hepatic cirrhosis, severe heart failure, oedema, elderly, renal impairment. Monitor for signs or fluid & electrolyte disturbance. Hepatic impairment, DM, gout, hyperlipidaemia, hypercalcae,ia, hyperuricaemia, ECG; LVH (Extrasystoles). May axacerbate or activate SLE in susecptible patients.
Other Drug Interactions
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May cause hyponatraemia when used with carbamazepine. May increase risk of toxicity when used with allopurinol or tetracyclines. Potentiates hypotensive effect of <!-- @page { margin: 0.79in } P { margin-bottom: 0.08in } --> <!-- @page { margin: 0.79in } P { margin-bottom: 0.08in } -->α blockers & ACE inhinbitors. Diuretic- induced hypokalaemia may increase the toxicity of digitalis glycosides and risk of arrhythmias when used with drugs that prolong QT inteval. May increase serum concentrations of lithium when used together. Concurrent use with alcohol, barbiturates & opoids may enhance diuertic - enhanced orthostatic hypotension. Antihypertensive effect may be reduced by corticosteriods, NSAIDs or carbenoxolone. May enhance the nephrotoxicity of NSAIDs. Enhnaces neuromuscular blocking action of competitive muscle relaxants. Impaired control of diabetics by oral hypoglycaemic agents.
Other Interactions
Information Not Available
Dosage
Oral
Oedema associated with heart failure:
Adult: Usual dosage: 25-100 mg dialy in the morning, may reduce to 25-50mg daily or intermittently. Up to 200 mg daily may be used as initial doses in severe cases.
Nephrogenic diabetes Insipidus
Adult: Initial dose: up to 100mg daily.
Child: Initially, 1-2 mg/kg/day in 1-2 divided doses; <6 months; up to 3 mg/kg/day.
Food(before/after)
Information Not Available
List of Contraindications
Hydro-Chlorothiazide and Pregnancy
Contraindicated in pregnancy
Hydro-Chlorothiazide and Lactation
Contraindicated in lactation
Hydro-Chlorothiazide and Children
Information Not Available
Hydro-Chlorothiazide and Geriatic
Information Not Available
Hydro-Chlorothiazide and Other Contraindications
Severe hepatic & renal impairment, Addison's disease, preexisting hypercalcaemia, anuria, sulphonamide allaergy. Pregnancy & lactation.
Storage
Information Not Available
Lab interference
Information Not Available
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