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Beclometasone information from DrugsUpdate  

See Available Brands of Beclometasone in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Beclometasone dipropionate or beclomethasone dipropionate, also referred to as beclometasone, is a potent glucocorticoid steroid. In the form of an inhaler (e.g. Becotide, Qvar), a wide number of brands of which are available, it is used for the prophylaxis of asthma. As a nasal spray (e.g. Beconase, Vancenase), it is used for the treatment of rhinitis (e.g. hayfever) and sinusitis. In some instances it is used by oral pathologists in the treatment of unusually severe canker sores. As a cream or ointment (trade name Propaderm) it is used to treat severe inflammatory skin disorders (e.g. eczema) unresponsive to less potent steroids, but is generally avoided in the treatment of psoriasis due to the risk of rebound on withdrawal.

Pharmacodynamics

Pharmacokinetics

Beclometasone controls the rate of protein synthesis, depresses the migration of polymorphonuclear leukocytes, fibroblasts, reverses capillary permeability and lysosomal stabilisation at the cellular level to prevent or control inflammation.


Absorption


Readily absorbed after local application.


Distribution


Rapidly distributed to all body tissues.


Metabolism


Mainly hepatic but also in other tissues including GI tract and lungs.


Excretion


Chiefly in the urine and as metabolites in the faeces.

Beclometasone Indications / Beclometasone Uses

Information Not Available

Beclometasone Adverse Reactions / Beclometasone Side Effects

Loss of skin collagen and SC atrophy; local hypopigmentation of deeply pigmented skin; dryness, irritation, epistaxis, rarely ulceration or perforation of the nasal septum; smell and taste disturbances; hoarseness and candidiasis of the mouth or throat.

Precautions

Information Not Available

Special Precautions

Active or doubtfully quiescent tuberculosis, paradoxical bronchospasm; children, elderly; pregnancy and lactation.

Other Drug Interactions

Information Not Available

Other Interactions

Information Not Available

Dosage

Topical/Cutaneous


Corticosteroid-responsive dermatoses Adult: Apply a 0.025% cream/ointment onto affected area.


Nasal


Treatment and prevention of allergic and non allergic rhinitis Adult: 100 mcg bid or 50 mcg 3-4 times daily in each nostril. Max: 400 mcg daily.


Inhalation Prophylaxis of asthma Adult: Initially, 600-800 mcg daily. Maintenance: 400 mcg daily in 2-4 divided doses. Child: As dipropionate: 50 or 100 mcg bid-qid or 100 or 200 mcg bid.


Inhalation


Severe asthma Adult: 250 mcg four times daily or 500 mcg bid. May be increased to 500 mcg 3-4 times daily if necessary. Max: 2 mg daily.


Special Populations


When switching from oral to inhalation steroid for stable asthmatics. Initially, the inhalation is added to existing oral steroid dosage. After 1 wk, oral dose is reduced by 2.5 mg prednisone or its equivalent. Similar reduction is made at wkly intervals depending on patient response. Reinstatement of oral steroid may be needed in times of stress or exacerbation of asthma. Inhalation of β-agonists should be done 5 min before the steroids.

Food(before/after)

Information Not Available

List of Contraindications

Beclometasone and Pregnancy

Caution when used during pregnancy


Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Beclometasone and Lactation

Caution when used during lactation

Beclometasone and Children

Information Not Available

Beclometasone and Geriatic

Information Not Available

Beclometasone and Other Contraindications

Hypersensitivity. Acute infections uncontrolled by antimicrobial chemotherapy.

Storage

Inhalation
Store at 15-30°C.

Nasal
Store at 15-30°C.

Topical/Cutaneous

Store at 15-30°C.

Lab interference

Inhalation
Store at 15-30°C.

Nasal
Store at 15-30°C.

Topical/Cutaneous

Store at 15-30°C.

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