Flunarizine information from DrugsUpdate
P - Contraindicated in pregnancy
L - Contraindicated in lactation
Flunarizine (brand name Sibelium) is a drug classified as a calcium channel blocker. Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia.
Pharmacodynamics
Pharmacokinetics
Flunarizine has H1-receptor blocking action and calcium-channel blocking effect. It has also been used as an adjunct epileptic therapy for patients refractory to standard treatment regimens.
Absorption
Absorbed well from the GI tract (oral).
Distribution
Highly lipophilic. Protein-binding: >90%.
Metabolism
Extensive.
Excretion
Via bile (as metabolites); 18 days (elimination half-life).
Flunarizine Indications / Flunarizine Uses
Information Not Available
Flunarizine Adverse Reactions / Flunarizine Side Effects
Drowsiness. Rarely wt gain, headache, depression, gastric pain, dry mouth, insomnia, extrapyramidal reactions, galactorrhoea.
Precautions
Information Not Available
Special Precautions
Driving or operating machinery, epilepsy, elderly, CVS disease, glaucoma.
Other Drug Interactions
Plasma levels reduced by phenytoin, carbamazepine, valproic acid.
Other Interactions
Information Not Available
Dosage
Oral
Prophylaxis of migraine, Prophylaxis of vertigo and vestibular disorders, Prophylaxis of peripheral and cerebrovascular disorders
Adult: 5-10 mg daily at bedtime.
Food(before/after)
May be taken with or without food
List of Contraindications
Flunarizine and Pregnancy
Contraindicated in pregnancy
Flunarizine and Lactation
Contraindicated in lactation
Flunarizine and Children
Information Not Available
Flunarizine and Geriatic
Information Not Available
Flunarizine and Other Contraindications
Pregnancy, lactation, GI or urinary tract obstruction, acute porphyrias
Storage
Oral
Store below 25°C
Lab interference
Oral
Store below 25°C
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