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Flunarizine information from DrugsUpdate  

See Available Brands of Flunarizine in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Flunarizine (brand name Sibelium) is a drug classified as a calcium channel blocker. Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia.



Flunarizine has H1-receptor blocking action and calcium-channel blocking effect. It has also been used as an adjunct epileptic therapy for patients refractory to standard treatment regimens.

Absorbed well from the GI tract (oral).

Highly lipophilic. Protein-binding: >90%.


Via bile (as metabolites); 18 days (elimination half-life).

Flunarizine Indications / Flunarizine Uses

Information Not Available

Flunarizine Adverse Reactions / Flunarizine Side Effects

Drowsiness. Rarely wt gain, headache, depression, gastric pain, dry mouth, insomnia, extrapyramidal reactions, galactorrhoea.


Information Not Available

Special Precautions

Driving or operating machinery, epilepsy, elderly, CVS disease, glaucoma.

Other Drug Interactions

Plasma levels reduced by phenytoin, carbamazepine, valproic acid.

Other Interactions

Information Not Available


Prophylaxis of migraine, Prophylaxis of vertigo and vestibular disorders, Prophylaxis of peripheral and cerebrovascular disorders
Adult: 5-10 mg daily at bedtime.


May be taken with or without food

List of Contraindications

Flunarizine and Pregnancy

Contraindicated in pregnancy

Flunarizine and Lactation

Contraindicated in lactation

Flunarizine and Children

Information Not Available

Flunarizine and Geriatic

Information Not Available

Flunarizine and Other Contraindications

Pregnancy, lactation, GI or urinary tract obstruction, acute porphyrias


Store below 25°C

Lab interference

Store below 25°C

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