Bacampicillin information from DrugsUpdate
LI - Lab *
Bacampicillin (INN) is a penicillin antibiotic. It is a prodrug of ampicillin with improved oral bioavailability. It is sold under the brand names Spectrobid (Pfizer) and Penglobe (AstraZeneca).
Pharmacodynamics
Pharmacokinetics
Bacampicillin has the antimicrobial action of ampicillin in vivo. It needs to be hydrolysed to ampicillin since it possesses no intrinsic activity.
Absorption Rapidly and absorbed in the GI tract.
Metabolism Hydrolysed in intestinal walls and plasma to ampicillin
Excretion About 75% of a dose is excreted in the urine within 8 hr as ampicillin
Bacampicillin Indications / Bacampicillin Uses
Information Not Available
Bacampicillin Adverse Reactions / Bacampicillin Side Effects
Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis. Nausea; vomiting; pseudomembranous colitis.
Precautions
Information Not Available
Special Precautions
Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitisation may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route. Discontinue in case of skin rash.
Other Drug Interactions
Probenecid prolongs T1/2 of bacampicillin. Bacteriostatic drugs e.g. chloramphenicol, tetracyclines; other antibacterials; anticoagulants.
Other Interactions
Information Not Available
Dosage
Oral Urinary tract infections Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral Gastroenteritis Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral Listeriosis Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral Biliary tract infections Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral Endocarditis Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral Meningitis Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral Otitis media Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral Peritonitis Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral Pneumonia Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral Septicaemia Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral Bronchitis Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral Perinatal streptococcal infections Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral Typhoid and paratyphoid fever Adult: 400-800 mg bid-tid. Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
Oral Uncomplicated gonorrhoea Adult: 1.6 g with 1 g probenecid as a single dose.
Food(before/after)
May be taken with or without food (May be taken w/ meals to reduce GI discomfort)
List of Contraindications
Bacampicillin and Pregnancy
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Bacampicillin and Lactation
Information Not Available
Bacampicillin and Children
Information Not Available
Bacampicillin and Geriatic
Information Not Available
Bacampicillin and Other Contraindications
Infectious mononucleosis, lymphatic leukemia, HIV infection; hypersensitivity to penicillins
Storage
Information Not Available
Lab interference
Information Not Available
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