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Adapalene information from DrugsUpdate  

See Available Brands of Adapalene in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions.It is currently marketed by Galderma under the trade names Differin in some countries, and Adaferin in India. In the United States, Adapalene is now being distributed as "Epiduo (TM) Gel." This acne treatment which is new to the market also contains benzoyl peroxide.


Adapalene in small concentrations is a moderator of cellular differentiation, keratinization, and inflammatory processes. It has both exfoliating and anti-inflammatory effects. The exact mode of action of adapalene is unknown.


Adapalene binds to specific retinoic acid nuclear receptors which normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Absorption Minimal (topical) Excretion Bile

Adapalene Indications / Adapalene Uses

Information Not Available

Adapalene Adverse Reactions / Adapalene Side Effects

Mild skin irritation, scaling, erythema, cutaneous dryness, sensations of stinging and burning, pruritus.


Information Not Available

Special Precautions

Patients with sunburn, eczema. Pregnancy, lactation. Avoid excessive exposure to sunlight or UV irradiation. Keep away from the eyes, lips, nostrils and mucous membranes. Do not apply to cuts, abrasions, scaly or flaky skin, or patches of sunburned skin. Use with caution with preparations containing sulfur, resorcinol, or salicylic acid.

Other Drug Interactions

Increased irritation may occur with medicated or abrasive soaps, products with a pronounced drying effect and those containing alcohol or astringents.

Other Interactions

Information Not Available


Topical/Cutaneous Acne Adult: As 0.1% solution/cream/gel: Apply thinly onto affected areas once daily at night after cleansing.


Information Not Available

List of Contraindications

Adapalene and Pregnancy

Caution when used during pregnancy Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Adapalene and Lactation

Caution when used during lactation

Adapalene and Children

Safety and efficacy not established in children less than 12 years.

Adapalene and Geriatic

Information Not Available

Adapalene and Other Contraindications



Topical/Cutaneous: Store below 25 ℃

Lab interference

Topical/Cutaneous: Store below 25 ℃

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