Saxagliptin information from DrugsUpdate
Saxagliptin, an anti-diabetic drug, is indicated for the treatment and management of type-2 diabetes in adults. Saxagliptin can be prescribed either as a monotherapy or as a combined therapy with insulin or sulphonylurea. Saxagliptin should be prescribed as a comprehensive treatment with diet, exercise and lifestyle modifications.
Pharmacodynamics
Saxagliptin inhibits enzymatic activity of DPP4 that leads to decreased levels of glucagon, glucagon-dependent insulin, GIP and GLP-1.
Pharmacokinetics
After oral administration, the drug achieves Cmax within 2 hours, and the absorption is influenced by high-fat meals. The drug is metabolized via the cytochrome P450 system. Saxagliptin is eliminated via the urine and hepatic pathways. The terminal half-life of Saxagliptin is 2.5-3.1 hours.
Saxagliptin Indications / Saxagliptin Uses
No information available
Saxagliptin Adverse Reactions / Saxagliptin Side Effects
Some of the commonly reported adverse events of Saxagliptin are headache, UTI and URI, ITP, abdominal pain, nausea or vomiting, gastroenteritis and hypoglycemia.
Precautions
Caution should be exercised while prescribing Saxagliptin to patients with pancreatitis, hypersensitivity to synthetic drugs, angioedema or exfoliative skin reactions. Monitor patients continuously while prescribing Saxagliptin with insulin or sulfonylurea.
Special Precautions
No information available
Other Drug Interactions
Saxagliptin may interact with quinolone antibiotics, olanzapine, macrolide antibiotics, HIV protease inhibitors, nefazodone, azole anti-fungal drugs and beta-blockers.
Other Interactions
Do not consume alcohol while taking Saxagliptin. It can cause serious hypoglycemia.
Dosage
The recommended adult dosage of Saxagliptin is 2.5-5 mg, once daily.
Food(before/after)
Saxagliptin can be taken before or after food intake
List of Contraindications
Saxagliptin and Pregnancy
USFDA pregnancy category B. Saxagliptin may not cause harm to an unborn foetus. Before Saxagliptin treatment, the patient should discuss with the physician, if they are planning for a pregnancy.
Saxagliptin and Lactation
Nursing mothers should consult a physician before taking Saxagliptin
Saxagliptin and Children
Saxagliptin is contraindicated in children.
Saxagliptin and Geriatic
No information available
Saxagliptin and Other Contraindications
No information available
Storage
No information available
Lab interference
No information available
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