Alpha-Lipoic Acid information from DrugsUpdate
Alpha-lipoic acid is a naturally occurring fatty acid that can be found in many foods such as yeast, spinach, broccoli, potatoes, and organ meats such as liver or kidney.
Alpha-lipoic acid has been used as a nutritional supplement and antioxidant.
Alpha-lipoic acid is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.
Pharmacodynamics
Pharmacokinetics
Information Not Available
Alpha-Lipoic Acid Indications / Alpha-Lipoic Acid Uses
Information Not Available
Alpha-Lipoic Acid Adverse Reactions / Alpha-Lipoic Acid Side Effects
Information Not Available
Precautions
Overdosage
Symptoms may include anorexia, lassitude, nausea and vomiting, constipation or diarrhoea, polyuria, nocturia, sweating, headache, thirst, somnolence and vertigo and hypercalcaemia. Management: Stop admin of alfacalcidol. Treatment is symptomatic and supportive. Ensure patient is well hydrated by i.v. infusion of saline (force diuresis). Monitor electrolytes, calcium levels, renal function, ECG (especially in patients on digitalis). Consider treatment with glucocorticosteroids, loop diuretics, bisphosphonates, calcitonin and haemodialysis with low calcium content.
Special Precautions
Pregnancy, lactation, renal impairment, infants, elderly. Monitor serum levels of calcium in patients with renal failure. Caution in hypercalciuria esp in those with history of renal calculi. Avoid in patients with hypersensitivity to inj. containing propylene glycol.
Other Drug Interactions
Thiazides may increase the risk of hypercalcaemia. Some antiepileptics e.g. carbamazepine, phenobarbital, phenytoin and primidone may increase vitamin D requirements. Rifampicin, isoniazid and corticosteroids may reduce the efficacy of vitamin D.
Other Interactions
Information Not Available
Dosage
Oral
Hypocalcaemia, Renal osteodystrophy, Hypoparathyroidism, Rickets or osteomalacia, Hypophosphataemia
Adult: Initially, 1 mcg daily. Maintenance: 0.25-1 mcg daily.
Child: Premature infants and neonates: 0.05-0.1 mcg/kg daily; <20 kg: 0.05 mcg/kg daily.
Elderly: 0.5 mcg daily.
Food(before/after)
Should be taken with food
List of Contraindications
Alpha-Lipoic Acid and Pregnancy
Information Not Available
Alpha-Lipoic Acid and Lactation
Information Not Available
Alpha-Lipoic Acid and Children
Information Not Available
Alpha-Lipoic Acid and Geriatic
Information Not Available
Alpha-Lipoic Acid and Other Contraindications
Information Not Available
Storage
Oral
Capsule: Store below 25°C. Liquid: Refrigerate at 2-8°C.
Lab interference
Oral
Capsule: Store below 25°C. Liquid: Refrigerate at 2-8°C.
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