Spironolactone + Torsemide information from DrugsUpdate
Spironolactone + Torsemide, a combination of diuretics, is prescribed for the treatment of salt-retention induced edema and hypertension.
Pharmacodynamics
Spironolactone:
The drug is a potassium-sparing diuretic with direct antagonist activity against aldosterone (competitive antagonism) in the distal tubules of nephron. Spironolactone is a synthetic 17-lactone steroidal formulation that increases secretion of water and sodium without interfering with potassium metabolism.
Torsemide:
Torsemide reduces edema and fluid retention by increasing the urinary output. These effects can reduce the risk of MI, stroke and renal disorders.
Pharmacokinetics
No information available
Spironolactone + Torsemide Indications / Spironolactone + Torsemide Uses
No information available
Spironolactone + Torsemide Adverse Reactions / Spironolactone + Torsemide Side Effects
Some of the commonly reported adverse events of Spironolactone + Torsemide are electrolyte imbalance with hypokalemia, dry mouth, metabolic alkalosis, hyperuricemia, abdominal cramps, anorexia, tinnitus and hearing loss.
Precautions
Spironolactone + Torsemide are contraindicated in patients with hypotension, cardiac arrhythmias, renal failure with oliguria or anuria, hepatic coma and/or pre-coma states. Spironolactone + Torsemide should not be prescribed to individuals with an allergy to diuretics.
Caution should be exercised before prescribing Spironolactone + Torsemide to patients with hyperuricemia, electrolyte imbalance and diabetes mellitus.
Special Precautions
No information available
Other Drug Interactions
No information available
Other Interactions
No information available
Dosage
The dosage and duration of Spironolactone + Torsemide therapy should be as prescribed by a physician.
Food(before/after)
Spironolactone + Torsemide can be taken before or after food intake
List of Contraindications
Spironolactone + Torsemide and Pregnancy
USFDA Pregnancy category of Spironolactone + Torsemide is unknown. Avoid taking Spironolactone + Torsemide, if you are in gestation.
Spironolactone + Torsemide and Lactation
Nursing mothers should consult a physician before taking Spironolactone + Torsemide
Spironolactone + Torsemide and Children
Spironolactone + Torsemide is contraindicated in children
Spironolactone + Torsemide and Geriatic
No information available
Spironolactone + Torsemide and Other Contraindications
No information available
Storage
No information available
Lab interference
No information available
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