Benzoyl Peroxide information from DrugsUpdate
Benzoyl peroxide is an organic compound in the organic peroxide family. It consists of two benzoyl groups joined by a peroxide group. It is one of the most important organic peroxides in terms of applications and the scale of its production. Benzoyl peroxide is used as an acne treatment, for improving flour, for bleaching hair and teeth, for polymerising polyester and many other uses.
Pharmacodynamics
Pharmacokinetics
Benzoyl peroxide has mild keratolytic effect and antimicrobial activity which is attributed to its oxidative property. It is active against S.epidermidis and P.acne.
Metabolism
Skin; converted to benzoic acid.
Excretion
Urine.
Benzoyl Peroxide Indications / Benzoyl Peroxide Uses
Information Not Available
Benzoyl Peroxide Adverse Reactions / Benzoyl Peroxide Side Effects
Excessive drying of skin, allergic dermatitis. May bleach fabrics or hair. Skin discoloration; skin rash, peeling, transient local oedema.
Precautions
Monitor
Assess and document skin condition before initial application and periodically throughout treatment. Monitor for side effects, including redness, scaling, dryness, or persistent itching or burning. Inform health care provider if noted and significant. If bothersome dryness or peeling occurs, consider reducing the frequency of application and/or the concentration of the medication.
Bleaching
Benzoyl peroxide is an oxidizing agent and may bleach hair and colored fabric.
Cross-sensitization
Cross-sensitization may occur with benzoic acid derivatives (eg, cinnamon, certain topical anesthetics).
Overdosage
Symptoms
Excessive scaling, erythema, edema.
Special Precautions
Discontinue if severe irritation develops. Restart with tolerable levels of treatment after irritiation has cleared. Do not use occlusive dressing. May cause dermatitis in allergic patients. Apply carefully near the eyes, mouth, neck and other mucous membranes as well as other sensitive areas.
Other Drug Interactions
PABA sunscreens may transiently discolour fabric
Other Interactions
Information Not Available
Dosage
Topical/Cutaneous
Acne
Adult: Apply a 2.5-10% preparation once or twice daily, often used with other antimicrobials.
Topical/Cutaneous
Decubitus/stasis ulcers
Adult: Apply a 20% lotion every 8-12 hours.
Food(before/after)
Information Not Available
List of Contraindications
Benzoyl Peroxide and Pregnancy
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Benzoyl Peroxide and Lactation
Information Not Available
Benzoyl Peroxide and Children
Information Not Available
Benzoyl Peroxide and Geriatic
Information Not Available
Benzoyl Peroxide and Other Contraindications
Hypersensitivity
Storage
Topical/Cutaneous
Store at 15-30°C
Lab interference
Topical/Cutaneous
Store at 15-30°C
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