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Methylcobalamin information from DrugsUpdate  

See Available Brands of Methylcobalamin in India

Methylcobalamin, an analogue of vitamin B12, is prescribed for the prevention and treatment of vitamin B12 deficiency, memory loss, psoriasis, pernicious anemia, homocysteinemia, atopic dermatitis and age-related macular degeneration.

Methylcobalamin is either prescribed as a monotherapy or as a combined therapy with other nutritional supplements including pyridoxine, folic acid and avocado oil.


No information available


No information available

Methylcobalamin Indications / Methylcobalamin Uses

No information available

Methylcobalamin Adverse Reactions / Methylcobalamin Side Effects

No significant adverse events were reported with Methylcobalamin use. In certain individuals, Methylcobalamin can cause serious allergic reactions, diarrhoea, thrombosis, anaphylactic reactions and urticaria. Methylcobalamin topical applications are found to be safe in psoriasis patients.


Methylcobalamin is contraindicated in patients with polycythemia rubra vera, megaloblastic anemia, cobalt or cobalamin allergy and Leber’s disease.

Special Precautions

No information available

Other Drug Interactions

Methylcobalamin may interact with chloramphenicol and cause aplastic syndrome.

Other Interactions

No information available


Oral formulations:
The recommended adult oral dosage of Methylcobalamin is 1-25 mcg/day and based on the recommended dietary allowance (RDAs) in accordance with age.
For pernicious anemia/B12 deficiency (Adults):
Consider administration of 300-10, 000 mcg/day. The evidential, effective dose is 647-1032 mcg/day.

For homocysteinemia (Adults):
Consider administration of 500 mcg of Methylcobalamin in combination with pyridoxine and folic acid.

Prophylaxis of age-related macular degeneration (Adults):
Consider administration of 1 mg of Methylcobalamin with pyridoxine and folic acid.

For atopic dermatitis (Adults):
As a topical application, apply 0.07% Methylcobalamin cream twice daily.

For treatment of Psoriasis (Adults):
Apply 0.7 mg of Methylcobalamin with avocado oil for 12 weeks, twice daily.


Methylcobalamin can be taken before or after food intake

List of Contraindications

Methylcobalamin and Pregnancy

In recommended doses, Methylcobalamin is likely safe during pregnancy.

Methylcobalamin and Lactation

In recommended doses, Methylcobalamin is likely safe during lactation.

Methylcobalamin and Children

The dosage and duration should be based on the patient’s condition and requirement

Methylcobalamin and Geriatic

No information available

Methylcobalamin and Other Contraindications

No information available


No information available

Lab interference

No information available

Methylcobalamin brands in India:

Cobadin Folizorb

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