Acebrophylline information from DrugsUpdate
Acebrophylline, a xanthine derivative, is prescribed as a bronchodilator for the treatment of bronchial asthma and COPD in adults. Acebrophylline alter mucus gel secretion phase by lowering viscosity and increasing the serous gel phase. By augmenting ciliary motility, Acebrophylline increases the mucociliary clearance.
Pharmacodynamics
Acebrophylline inhibits intracellular phosphodiesterase associated with cAMP levels and facilitates bronchial muscles relaxation. Acebrophylline selectively inhibits phosphatidylcholine and phospholipase A, TNF-alpha and leukotrienes. Inhibition of such pro-inflammatory mediators can significantly reduce the airway inflammation and obstruction in chronic stages.
Pharmacokinetics
After oral administration, the drug is rapidly absorbed in the stomach and Cmax can be reached within two hours. The plasma half-life of Acebrophylline varies from 4-9 hours. The drug is primarily metabolized in the liver and eliminated via the urine.
Acebrophylline Indications / Acebrophylline Uses
No information available
Acebrophylline Adverse Reactions / Acebrophylline Side Effects
Acebrophylline can cause glycosuria, epigastric pain, low blood pressure, GI discomfort or distension, anorexia, drowsiness, breathing difficulties, albuminuria, hyperglycemia, leucocytosis, mild skin reactions, fever, fatigue and nasal inflammation.
Precautions
Acebrophylline is contraindicated in patients with hypotension, acute myocardial infarction, impaired hemodynamics, hepatic or/and renal disorders, Ambroxol allergy, GI disorders, convulsion, arrhythmia, CAD, cardiac insufficiency and hyperthyroidism.
Special Precautions
No information available
Other Drug Interactions
Acebrophylline should not be prescribed concomitantly with lincomycin, clindamycin, erythromycin, allopurinol, barbiturates, quinolone derivatives, oxytetracycline, cimetidine, furosemide, anticoagulants, oligomycin, phenytoin and reserpine.
Other Interactions
No information available
Dosage
For COPD and bronchial asthma (Adults):
Consider administration of 100 mg of Acebrophylline, twice daily.
Food(before/after)
Acebrophylline can be preferably taken after meals to avoid GI discomfort.
List of Contraindications
Acebrophylline and Pregnancy
No information available about USFDA pregnancy category. However, Acebrophylline is contraindicated in pregnancy.
Acebrophylline and Lactation
Nursing mothers should consult a physician before taking Acebrophylline
Acebrophylline and Children
No information available
Acebrophylline and Geriatic
No information available
Acebrophylline and Other Contraindications
No information available
Storage
Store at room temperature, 15-30° C (59-86°F). Keep away from moisture
Lab interference
Store at room temperature, 15-30° C (59-86°F). Keep away from moisture
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