Silodosin information from DrugsUpdate
Silodosin, an alpha adrenergic blocker, is prescribed for the treatment of benign prostatic hyperplasia (BPH). The drug aids relaxation of prostate and bladder neck muscles and facilitates micturition.
Pharmacodynamics
Silodosin is a selective blocker of post-synaptic alpha-1 adrenergic receptors in bladder base, prostate, prostate urethra, bladder neck and prostatic capsule. Selective blocking of such receptors results in smooth muscle relaxation and facilitated urine flow with reduction of BPH symptoms.
Pharmacokinetics
The oral bioavailability of Silodosin is about 32%. The absorption rate is affected by moderate fat and calorie meals. The apparent Vss of Silodosin is 49.5 L, and about 97% of the drug is bound to plasma proteins. The drug is primarily metabolized by hepatic enzymes including cytochrome P450 pathway. Silodosin is excreted by urine and feces.
Silodosin Indications / Silodosin Uses
Information not available
Silodosin Adverse Reactions / Silodosin Side Effects
Silodosin can cause painful penile erection that may last over four hours, abnormal ejaculation, rhinorrhoea, headache, diarrhoea, dizziness and fainting.
Precautions
Silodosin may impair thinking and mental alertness. Do not drive vehicles or operate heavy machineries while taking Silodosin. Avoid going out in the hot sun or in extreme weather conditions, it may lead to serious dehydration. Do not wake up fast from bed in the morning. It may cause fall accident. Silodosin is contraindicated in patients with severe hepatic or renal disorders.
An adjusted dosage may be needed for patients with prostate malignancy, hepatic and renal disorders. Avoid using Silodosin at least before or after cataract surgery.
Special Precautions
Information not available
Other Drug Interactions
Silodosin may interact with quinidine, imatinib, conivaptan, INH, anti-fungal drug, clarithromycin, erythromycin, anti-depressants, calcium channel blockers, sildenafil, immunosuppressive drugs and quinidine.
Other Interactions
Do not consume alcohol while taking Silodosin
Dosage
For Benign Prostatic Hyperplasia (Adults):
The recommended oral dosage is 8 mg/day.
Food(before/after)
Silodosin should be preferably taken with meals.
List of Contraindications
Silodosin and Pregnancy
No information available
Silodosin and Lactation
No information available
Silodosin and Children
Silodosin is contraindicated in children
Silodosin and Geriatic
No information available
Silodosin and Other Contraindications
No information available
Storage
Store at 20-25°C.
Lab interference
Store at 20-25°C.
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