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BCG information from DrugsUpdate  

See Available Brands of BCG in India

BCG (Bacillus Calmette and Guérin) is prescribed for the treatment off bladder cancer without evidences of metastasis. The drug should be administered directly into the bladder that results in inflammation and elicited natural killer cell mediated immune response against tumor cells.

Pharmacodynamics

BCG elicits an acute, local inflammatory reaction with sub-acute granulomatous reactions with lymphocyte and macrophages in the urothelium and lamina propria of the urinary bladder. The anti-tumor activity of BCG is T—lymphocyte dependent.

Pharmacokinetics

No information available

BCG Indications / BCG Uses

No information available

BCG Adverse Reactions / BCG Side Effects

BCG can cause mild nausea, painful micturition, nausea, vomiting, chills, fever, flu-like symptoms, changes in urination frequency, lower back pain, eye pain or redness, photophobia, headache, mild skin rashes, fatigue, pain or edema in testicles and urine incontinence.

Precautions

BCG is contraindicated in patients with tuberculosis, immune deficiency, bladder infections, active infections, pace makers, history of aneurysm, organ transplantation, myasthenia gravis, hematuria, bladder surgery, patient receiving corticosteroid therapy, bladder radiotherapy or surgery within the past two weeks.

Special Precautions

No information available

Other Drug Interactions

BCG may interact with anti-cancer drugs, radiation, cyclosporine, sirolimus, basiliximab, mycophenolate, azathioprine, corticosteroids and other  immunosuppressive drugs.

Other Interactions

Co-administration of BCG with antibiotics results in decreased effectiveness of antibiotics.

Dosage

BCG is only for intravesical instillation only. Do not inject BCG as IM/IV/SC. One vial contains 81 mg of lyophilized BCG. The powder should be reconstituted with 3 ml of diluent.

Food(before/after)

No information available

List of Contraindications

BCG and Pregnancy

USFDA pregnancy category C. May be or may not be harmful to an unborn baby.

BCG and Lactation

It is not known whether BCG can pass through the breast milk or not. Breastfeeding mothers should avoid nursing while receiving BCG.

BCG and Children

No information available

BCG and Geriatic

No information available

BCG and Other Contraindications

No information available

Storage

Store at 20-25°C.

Lab interference

Store at 20-25°C.

BCG brands in India:

Bcg

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