logo image

Rabeprazole information from DrugsUpdate  

See Available Brands of Rabeprazole in India

P - Caution when used during pregnancy
FI - Food *

Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It was developed by Eisai Co. and is marketed by Janssen-Cilag as rabeprazole sodium under the brand names AcipHex in the US, Pariet in Japan and Canada, & Rablet in India.



Rabeprazole is a PPI that suppresses gastric acid secretion by inhibiting the gastric H+/K+ ATPase at the secretory surface of the gastric parietal cell.

1 hour.

24 hours

Oral bioavailability: about 52% and peak plasma concentrations are reached about 3.5 hr after oral admin.

Protein-binding: 97%.

Extensively metabolised in the liver by cytochrome P450 isoenzymes.

Metabolites are mainly excreted in the urine (90%). Half-life: about 1 hour.

Rabeprazole Indications / Rabeprazole Uses

Information Not Available

Rabeprazole Adverse Reactions / Rabeprazole Side Effects

Headache, diarrhoea, rash, infection and flu-like syndrome. Dizziness, fatigue, constipation, nausea and vomiting.

Potentially Fatal: Anaphylaxis, agranulocytosis.


Information Not Available

Special Precautions

Severe hepatic impairment, gastric malignancy. May increase the risk of GI infections due to acid suppressive effects. Pregnancy.

Other Drug Interactions

May reduce absorption of ketoconazole and itraconazole. May prolong the elimination of diazepam, phenytoin and warfarin.

Other Interactions

Food Interaction
Delayed absorption with high-fat meals.


Gastro-oesophageal reflux disease
Adult: For erosive oesophagitis: 20 mg once daily in the morning for 4-8 wk. Maintenance: 10-20 mg once daily according to response. For non-erosive oesophagitis: 10 mg once daily for 4 wk, upon symptom resolution, may continue with 10 mg once daily when necessary.

Hypersecretory conditions
Adult: Initially, 60 mg daily adjusted according to response. Max dose: 120 mg daily.


Active peptic ulcer disease
Adult: 20 mg daily given for 4-8 wk for duodenal ulcer and 6-12 wk for gastric ulcer.


H.pylori infection
Adult: As a combination with two antibacterials: 20 mg bid combined with clarithromycin 500 mg bid and either amoxicillin 1 g bid or metronidazole 400 mg bid. To be taken for a week.


Delayed-release: May be taken with or without food.

List of Contraindications

Rabeprazole and Pregnancy

Caution when used during pregnancy.

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Rabeprazole and Lactation


Rabeprazole and Children

Safety and efficacy not established in the short-term treatment of GERD in children younger than 12 yr of age. For other indications, safety and efficacy not established.

Rabeprazole and Geriatic

Information Not Available

Rabeprazole and Other Contraindications



Store at 15-30°C

Lab interference

Store at 15-30°C

© 2011-2023 DrugsUpdate.com. Disclaimer | Site Map

  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.