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For the treatment of hypertension, by Takeda; Approved February 2011
Edarbi (azilsartan medoxomil), a prodrug, is hydrolyzed to azilsartan in the gastrointestinal tract during absorption. Azilsartan is a selective AT1 subtype angiotensin II receptor antagonist. It's mechanism of action is to lower blood pressure by inhibiting action of vasopressor hormone Angiotensin II, a polypeptide that causes vasoconstriction, increased blood pressure and aldosterone release.
Edarbi is specifically indicated for the treatment of hypertension, alone or in combination with other antihypertensive agents.
Edarbi is supplied as a tablet for oral administration. The recommended initial dose in adults is 80 mg taken orally once daily.
Adverse events associated with the use of Edarbi may include, but are not limited to, the following:
Mechanism of Action
Edarbi, a prodrug, is hydrolyzed to azilsartan in the gastrointestinal tract during absorption. Azilsartan is a selective AT1 subtype angiotensin II receptor antagonist. Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzymes (ACE, kinase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Azilsartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is, therefore, independent of the pathway for angiotensin II synthesis.