A novel research conducted has identified genetic variations that lead to increased risk of hypertriglyceridemia (HTG). Hypertriglyceridemia increases risk of heart disease and stroke. The disease is also linked to obesity, diabetes and pancreatitis.
Certainly, the study can lead to newer drugs based on its conclusion.
The study had more than 500 patients to identify the genetic foundation of HTG by two different techniques.
One of the techniques used was based on DNA microarrays, or "gene chips" that home in on known common genetic mutations.
Sweeping the whole genetic code for evidence of previously unknown rare variants associated with disease was the second method.
The genes which influence lipid or fatty molecule levels in the blood are APOA5, GCKR, LPL and APOB.
The scientists also observed that various commonly known and rare gene mutations appeared to influence these genes and also were linked to having HTG.
28 per cent of HTG patients have rare variants in about twice the amount seen in healthy people.
Dr Robert Hegele, who led the study said, "It's instructive that one single gene is not solely responsible for high triglyceride levels, but rather a mosaic of both common and rare variations in several genes,"
"It means that to get a full picture of a patient's genetic risk, you need to consider both common and rare variants in many genes simultaneously, and to use methods that will detect both types of variation." he further added.
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