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Tdap vaccine safe during pregnancy


Tetanus-diptheria-pertussis (Tdap) vaccine was found to be safe for inborn infant, if administered during the last trimester of gestation, a recent study suggested. The vaccine does not increase the risk of low birth weight, pre-eclampsia and pre-term delivery, according to the study was published in the Journal of the American Medical Association.


Vaccine is the prime choice of prophylaxis to prevent pertussis in neonates. The present study supported the safety of Tdap vaccine in pregnancy. However, babies less than 60 days old cannot be vaccinated for pertussis. If vaccinated between 27 and 36 weeks of pregnancy, maternal antibodies might be passed to inborn neonate, said Dr. Elyse Kharbanda, HealthPartners Institute for Education and Research.


The safety of Tdap was assessed by reviewing medical data of 123, 000 pregnancies and live birth cases between 2010 and 2012. Among the subjects, one out of five women received Tdap vaccine. No increased risk of preterm delivery, pre-eclampsia and low birth weight was observed in vaccinated and non-vaccinated women. However, slightly increased risk of chorioamnionitis was observed in vaccinated women.

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