Daily administration of low-dose aspirin may increase the chance of conception and successful childbirth in women who suffered recent pregnancy loss. The study was conducted by the researchers at the National Institutes of Health, published in the Lancet.
The largest-ever, placebo-controlled, randomized study was led by Dr. Enrique Schisterman. The study included 1000 women with history of stillbirth or miscarriage. All the participants were aged between 18 and 40 years of age and were on treatment for pregnancy loss. The subjects were randomly assigned to receive either low-dose aspirin (81 gm/day) with folic acid treatment or a placebo with folic acid.
The participants were followed-up for six menstrual cycles. If the subjects have achieved pregnancy, they were followed-up until delivery. Women who were at 36 weeks of pregnancy were asked to stop aspirin treatment. About 58% of women who were on aspirin became pregnant and delivered healthy off-spring, compared to 53% in the placebo group.
However, pregnancy loss was reported in 13% of aspirin takers against 12% in the placebo group. No significant differences in overall pregnancy rates loss between the two groups. The study confirmed that aspirin is not effective against pregnancy loss, the authors concluded.
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