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Fulvestrant information from DrugsUpdate  

See Available Brands of Fulvestrant in India

Fulvestrant, an anti-estrogen drug, is prescribed for the treatment of estrogen-related breast cancers. The drug inhibits the action of estrogen and prevents the growth of estrogen-dependent cancer cells. Fulvestrant is also prescribed in postmenopausal women with drug-resistant breast cancer.

Pharmacodynamics

Fulvestrant down regulates estrogen and progesterone receptors with proportional to dosage. The down regulation of such pathway is linked with an absolute decrease in Ki67 labelling index, a biomarker of cell proliferation.

Pharmacokinetics

The steady state concentrations can be reached within 4 weeks of multiple dosing of Fulvestrant. The apparent volume of distribution of Fulvestrant is 3-5 L/kg with plasma protein binding rate particularly to LDL, HDL and VLDL. The drug is metabolized via glucuronic conjugation, aromatic hydroxylation and oxidation. Fulvestrant is rapidly excreted via hepatobiliary route and mostly excreted via feces with an apparent half-life of about 40 days.

Fulvestrant Indications / Fulvestrant Uses

No information available

Fulvestrant Adverse Reactions / Fulvestrant Side Effects

Fulvestrant can cause thrombocytopenia, hepatic disorders and bleeding or clotting disorders.

Precautions

No information available

Special Precautions

No information available

Other Drug Interactions

Patients on warfarin treatment may need a dose adjustment while taking Fulvestrant.

Other Interactions

No information available

Dosage

The recommended dosage of Fulvestrant is 500 mg as intramuscular injections. The injection should be administered slowly into the buttocks (1-2 minutes/injections), and the injections should be continued on days 1, 15 and 29 and thereafter.

Food(before/after)

No information available

List of Contraindications

Fulvestrant and Pregnancy

Contraindicated in pregnancy
USFDA pregnancy category D. Fulvestrant can harm the unborn fetus. Perform pregnancy tests before using Fulvestrant. Use effective contraceptive modes to prevent unintended pregnancies while taking Fulvestrant.

Fulvestrant and Lactation

Nursing mothers should consult a physician before taking Fulvestrant

Fulvestrant and Children

No information available

Fulvestrant and Geriatic

No information available

Fulvestrant and Other Contraindications

No information available

Storage

Store at 20-25°C.

Lab interference

Store at 20-25°C.

Fulvestrant brands in India:

Faslodex Fulvenat

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