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Dextroamphetamine information from DrugsUpdate  

See Available Brands of Dextroamphetamine in India

Dextroamphetamine, a stimulant, is prescribed for the treatment of narcolepsy and attention deficit hyperactive disorder (ADHD). The drug augment CNS neurochemicals that result in stimulation, accelerated heart beats and elevated blood pressure.

Pharmacodynamics

No information available

Pharmacokinetics

No information available

Dextroamphetamine Indications / Dextroamphetamine Uses

No information available

Dextroamphetamine Adverse Reactions / Dextroamphetamine Side Effects

Dextroamphetamine can cause hallucinations, behavioural changes including motor tics, unusual behaviours, light-headedness, tachycardia, dizziness, diarrhoea or constipation, loss of libido, difficulty to attain orgasm, impotence, insomnia, dry mouth, anorexia, unexplained weight loss, sudden death and convulsion.

Precautions

Dextroamphetamine is contraindicated in patients with hypertension, overactive thyroid, glaucoma, agitation, anxiety, arteriosclerosis, history of substance abuse or alcohol addiction, congenital heart defects, Tourette’s syndrome, suicidal thoughts, depression, bipolar disorders, seizure and history of allergy to synthetic dyes in foods.

Special Precautions

No information available

Other Drug Interactions

Dextroamphetamine may interact with other drugs including methenamine, antacids, acetazolamide, diuretics, lithium, anti-secretory drugs, phenytoin, chlorpromazine, haloperidol, ethosuximide, anti-histamines, propoxyphene, reserpine and antidepressants.

Other Interactions

Drinking alcoholic beverages will impair the amphetamine metabolism and increases the level of drug in the blood that may lead to serious side effects.

Dosage

Narcolepsy (Adults):
Tablets: Start with an oral initial dose of 10 mg/day upon awakening. The maintenance dose should be increased (as increments of 10 mg) up to 60 mg/day in 3 divided doses.
 
Extended Release Capsules:  Start with an oral initial dose of 10 mg/day upon awakening. The maintenance dose should be increased (as increments of 10 mg) up to 60 mg/day in 3 divided doses.
 
Oral Solution: 5 – 60 mg/day in divided doses. The dosage can be adjusted according to patient’s requirement and clinical response.
 
Narcolepsy (Pediatrics):

Tablets: >6 years: Not indicated
6 to 12 years: Start with an oral initial dose of 5 mg/day upon awakening. The maintenance dose should be increased (as increments of 5 mg) up to 60 mg/day in 2-3 divided doses.

<= 12 years: Start with an oral initial dose of 10 mg/day upon awakening. The maintenance dose should be increased (as increments of 10 mg) up to 60 mg/day in 2-3 divided doses.
 
Extended Release Capsules:

> 6 years: Not indicated

6 to 12 years:
Initial Dose: Start with an oral initial dose of 5 mg/day upon awakening. The maintenance dose should be increased (as increments of 5 mg) up to 60 mg/day in 2-3 divided doses.
 
<= 12 years:
Initial Dose: Start with an oral initial dose of 10 mg/day upon awakening. The maintenance dose should be increased (as increments of 10 mg) up to 60 mg/day in 2-3 divided doses.

Attention Deficit Hyperactive Disorder (Pediatrics):

Tablets: >3 years: Not indicated

3 to 5 years: Start with an oral initial dose of 2.5 mg/day upon awakening. The maintenance dose should be increased (as increments of 5 mg) up to 40 mg/day in 2-3 divided doses.

<= 6 years: Start with an oral initial dose of 5 mg/day upon awakening. The maintenance dose should be increased (as increments of 5 mg) up to 40 mg/day in 2-3 divided doses.
 
Extended Release Capsules:
 
>6 years: Not indicated
<= 12 years: Start with an oral initial dose of 10 mg/day upon awakening (even in cases switched from amphetamine). The maintenance dose should be increased (as increments of 10 mg) up to 40 mg/day in 2-3 divided doses. Whenever possible or upon the disappearance of symptoms, the treatment should be stopped gradually.

Food(before/after)

May be taken with or without food

List of Contraindications

Dextroamphetamine and Pregnancy

Contraindicated in pregnancy
USFDA Category C: Dextroamphetamine may be or may not be harmful to an unborn foetus. Consult a healthcare provider if you are in gestation or planning to become have a baby during Dextroamphetamine treatment. Gestational administration of Dextroamphetamine increase risk of premature delivery and decreased baby weight with symptoms of withdrawal symptoms in infants.

Dextroamphetamine and Lactation

Dextroamphetamine can pass to the infant through breast milk. Dextroamphetamine treatment should be avoided in nursing mothers.

Dextroamphetamine and Children

Prolonged use of Dextroamphetamine may impair the child’s growth rate. Consult a doctor if the Dextroamphetamine treated child is experiencing such problems. Do not self-medicate children younger than 3 years old, without a paediatrician’s advice.

Dextroamphetamine and Geriatic

No specific information

Dextroamphetamine and Other Contraindications

Information not available

Storage

Store at 20-25°C.

Lab interference

Store at 20-25°C.

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