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Bendamustine information from DrugsUpdate  

See Available Brands of Bendamustine in India

Bendamustine, an anti-cancer drug, is prescribed for the treatment of chronic lymphocytic leukaemia. The drug is also prescribed for the treatment of indolent B-cell non-Hodgkin’s lymphoma that is drug-resistant to other therapies.

Pharmacodynamics

Bendamustine forms a covalent bond with nucleophilic moieties that result in interstand DNA crosslinks. The bifunctional covalent cross linking leads to chemical cell death.

Pharmacokinetics

The Cmax occurs typically by the completion of intravenous infusion of Bendamustine. About 94-96% of the drug can bound to plasma proteins, and the property is dose-independent. The Vss of Bendamustine is about 25 L with the free distribution in red blood cells (RBCs). The drug is predominantly metabolized by hydrolysis reaction via CYP1A2. The drug is mostly excreted via feces with a clearance rate of 700 ml/hour. The terminal plasma half-life of administered drug differs with dose. Negligible or no accumulation of drug is reported after 2 days Bendamustine IV administration (28 days treatment)

Bendamustine Indications / Bendamustine Uses

No information available

Bendamustine Adverse Reactions / Bendamustine Side Effects

Some of the serious adverse events of Bendamustine are skin rashes, muscle weakness, cold symptoms, allergic reactions, fever, chills, poorly-healed oral cankers, overactive reflexes, bradycardia or tachycardia and hematuria. Other non-serious adverse events of Bendamustine are injection-site reactions, mild skin rashes, headache, edema in extremities and anorexia.

Precautions

Bendamustine is contraindicated in smokers, patients with hepatic diseases, metabolic disorders, infections, immune disorders, liver diseases and renal disorders. Bendamustine may impair thinking and mental alertness. Do not use drive vehicles or operate machineries while taking Bendamustine.

Special Precautions

No information available

Other Drug Interactions

Bendamustine may interact with thiabendazole, ciprofloxacin, carbamazepine, barbiturates, fluvoxamine, cimetidine and omeprazole.

Other Interactions

No information available

Dosage

Chronic Lymphocytic Leukemia (Adults):
The recommended adult dosage of Bendamustine for treatment of chronic lymphocytic leukaemia is 100 mg/m2, IV, on days 1 & 2 of 28 days cycle. The treatment can be continued up to 6 cycles. The infusion should be administered over 30 minutes.
Dosage modifications may be needed in case of hematological toxicity. In such cases 50 mg/m2 on days 1&2 of each cycle. In severe toxicity, the dosage can be reduced to 25 mg/m2 on days 1 and 2 of each cycle. In case of severe non-hematological toxicity, 50 mg/m2 on days 1 & 2 of each cycle should be administered.
Non-Hodgkin's Lymphoma (Adults):
The recommended adult dosage of Bendamustine for treatment of chronic lymphocytic leukaemia is 120 mg/m2, IV, on days 1 & 2 of 21 days cycle. The treatment can be continued up to 8 cycles. The infusion should be administered over 60 minutes.
Dosage modifications may be needed in case of hematological toxicity. In such cases 90 mg/m2 on days 1 & 2 of each cycle. In severe toxicity, the dosage can be reduced to 60 mg/m2 on days 1 and 2 of each cycle. In case of severe non-hematological toxicity, 60-90 mg/m2 on days 1 & 2 of each cycle should be administered.

Food(before/after)

No information available

List of Contraindications

Bendamustine and Pregnancy

Contraindicated in pregnancy
USFDA pregnancy category D. Bendamustine can harm the unborn fetus. Perform pregnancy tests before using Bendamustine. Use effective contraceptive modes to prevent unintended pregnancies while taking Bendamustine.

Bendamustine and Lactation

It is unclear whether the drug could pass through the breast milk to a breast feeding baby. Consult your physician before taking Bendamustine, if you are nursing mother.

Bendamustine and Children

No information available

Bendamustine and Geriatic

No information available

Bendamustine and Other Contraindications

No information available

Storage

Store at 20-25°C.

Lab interference

Store at 20-25°C.

Bendamustine brands in India:

Bendit Bimode Maxtorin Mustin Purplz Rolanda

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