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Atovaquone information from DrugsUpdate  

See Available Brands of Atovaquone in India

Atovaquone is an anti-parasitic drug that is prescribed for the prophylaxis and treatment of Pneumocystitis carinii.

Pharmacodynamics

No information available

Pharmacokinetics

No information available

Atovaquone Indications / Atovaquone Uses

No information available

Atovaquone Adverse Reactions / Atovaquone Side Effects

Atovaquone may cause jaundice-like symptoms such as nausea, dark-coloured urine, yellow discoloration of eyes and skin, anorexia. Other adverse events of Atovaquone are fever, bleeding risks, bronchospasm with cough, pharyngitis, urticaria, unusual fatigue, GI upset, insomnia, flushing and myalgia.

Precautions

Do not use Atovaquone in patients with hepatic and/or intestinal disorders.

Special Precautions

Atovaquone may interact with rifabutin, carbamazepine, rifampicin and clozapine.

Other Drug Interactions

Drinking alcoholic beverages will impair the Atovaquone metabolism, and increases the level of drug in the blood that may lead to serious side effects.

Other Interactions

Dosage

Adults:
For treatment of Pneumocystis carinii Pneumonia:
Oral dose of Atovaquone 750 mg, twice daily for 21 days. Should consider other therapeutic dose, if symptoms persists or worsens.
 
Prophylaxis against Pneumocystis Pneumonia:
Oral dose of 1500 mg Atovaquone once daily

For treatment of Babesiosis:
Concomitant therapy of oral Atovaquone, 750 mg, twice daily with Azithromycin (as prescribed).
 
Treatment of Malaria:
Oral Atovaquone 500 – 750 mg, twice daily for 7 days with other anti-malarial drugs.
 
Toxoplasmosis:
Oral Atovaquone 750 mg, every 6 hours for 2-6 months. For maintenance therapy, same dose for every 6-8 hours. For treatment of Toxoplasmosis, Atovaquone should be given as a combined therapy with leucovorin and pyrimethamine or with sulfadiazine.
 
Pediatric:
Pneumocystis Pneumonia treatment:
1 month to 12 years: 20 mg/kg, oral, twice daily
13 years or older: 750 mg, oral, twice daily for 21 days

Maximum daily dose should not exceed more than 1500 mg/day.

Pneumocystis Pneumonia Prophylaxis:
1 to 3 months: 30 mg/kg, oral, once daily
4 months up to 2 years: 45 mg/kg, oral, once daily
2 to 12 years: 30 mg/kg, oral, once daily
13 years or older: 1500 mg, oral, once daily

Maximum daily dose should not exceed more than 1500 mg/day.

Treatment of Babesiosis:
1 to 12 years: 20 mg/kg, oral, twice daily with azithromycin (12 mg/kg, once daily) for 7 to 10 days

13 years or over: 750 mg, oral, twice daily with azithromycin (as prescribed) for 7 to 10 days

Maximum dose: 1500 mg/day

Food(before/after)

Take Atovaquone with a meal for best results

List of Contraindications

Atovaquone and Pregnancy

Contraindicated in pregnancy
FDA pregnancy category C. May be or may not be harmful to an unborn baby. Consult your doctor if you are in gestation or planning to have a baby.

Atovaquone and Lactation

Nursing mothers should consult the healthcare provider before Atovaquone treatment.

Atovaquone and Children

No information available

Atovaquone and Geriatic

No specific information available

Atovaquone and Other Contraindications

Storage

Store at 20-25°C.

Lab interference

Store at 20-25°C.

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