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Cetrorelix information from DrugsUpdate  

See Available Brands of Cetrorelix in India

P - Contraindicated in Pregnancy
L - Contraindicated in Lactation
LI - Lab *

Cetrorelix acetate is an injectable gonadotropin-releasing hormone antagonist (GnRH antagonist). A synthetic decapeptide, it is used to treat hormone-sensitive cancers of the prostate and breast (in pre-/perimenopausal women) and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, cetrorelix is used in assisted reproduction to inhibit premature luteinizing hormone surges.

Pharmacodynamics

Cetrorelix, a synthetic decapeptide analog of naturally occurring gonadorelin, is a gonadorelin antagonist. It competitively blocks gonadorelin receptors on the anterior piyuitary gonadotroph and the subsequent transduction pathway, inducing a rapid, reversible suppression of gonadotrophin secretion.

Pharmacokinetics

Duration: 4 days for a single 3-mg dose.

Cetrorelix Indications / Cetrorelix Uses

In Assisted reproductive technologies.

Cetrorelix Adverse Reactions / Cetrorelix Side Effects

Mild and transient reactions at Inj site, nausea, headache, ovarian hyperstimulation syndrome, systemic hypersensitivity reactions.

Special Precautions

Women with active allergic conditions or a history of allergies; childn; elderly >65 yrs.

Dosage

Subcutaneous


Assisted reproductive technologies


Adult: As acetate: equiv to 0.25 mg cetrorelix either in the morning beginning on the day 5 or 6 of ovarian stimulation or in the evening beginning on day 5, and continued until ovulation induction. Alternatively, a single dose equiv to 3 mg cetrorelix on day 7,; if follicle growth does not allow ovulation induction within 4 days, additional doses of 250 mcg once daily may be given until the day of ovulation induction.

List of Contraindications

Cetrorelix and Pregnancy

Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

Cetrorelix and Other Contraindications

Hypersensitivity. Moderate to severe renal or hepatic impairment. Women with severe allergic conditions. Pregnancy and lactation.

Lab interference

Information Not Available.

Cetrorelix brands in India:

Cetace Cetrotide Ovurelix

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